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- NCIT_C111794 IAO_0000115 "The free carboxy-terminal intracellular domain (ICD) of a notch family protein, which is a product of regulated intramembrane proteolysis mediated by the gamma-secretase enzyme complex. This protein fragment is involved in transcriptional regulation of target genes." @default.
- NCIT_C111794 NCIT_NHC0 "C111794" @default.
- NCIT_C111794 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C111794 NCIT_P108 "Notch Receptor Intracellular Domain" @default.
- NCIT_C111794 NCIT_P207 "C3828777" @default.
- NCIT_C111794 NCIT_P98 "Full-length notch proteins are post-translationally cleaved by furin to produce a disulfide bound, two-chain protein that is expressed on the cell surface. Once a notch ligand binds the extracellular portion, the larger amino-terminal portion is released from the cell surface and the remaining portion of the receptor, termed the Notch extracellular truncated (NEXT) domain is endocytosed. During endocytosis, NEXT is cleaved sequentially by an ADAM family secretase followed by intramembrane cleavage by gamma-secretase, which allows the notch intracellular domain to dissociate from the membrane and translocate into the nucleus." @default.
- NCIT_C111794 NCIT_R53 NCIT_C17710 @default.
- NCIT_C111794 NCIT_R53 NCIT_C17828 @default.
- NCIT_C111794 NCIT_R53 NCIT_C19077 @default.
- NCIT_C111794 NCIT_R53 NCIT_C21049 @default.
- NCIT_C111794 NCIT_R53 NCIT_C21050 @default.
- NCIT_C111794 NCIT_R53 NCIT_C28498 @default.
- NCIT_C111794 normalizedInformationContent "100" @default.
- NCIT_C111794 referenceCount "1" @default.
- NCIT_C111794 hasExactSynonym "NICD" @default.
- NCIT_C111794 hasExactSynonym "Neurogenic Locus Notch Homolog Protein ICD" @default.
- NCIT_C111794 hasExactSynonym "Neurogenic Locus Notch Homolog Protein Intracellular Domain" @default.
- NCIT_C111794 hasExactSynonym "Notch ICD" @default.
- NCIT_C111794 hasExactSynonym "Notch Intracellular Domain" @default.
- NCIT_C111794 hasExactSynonym "Notch Receptor Intracellular Domain" @default.
- NCIT_C111794 type Class @default.
- NCIT_C111794 isDefinedBy ncit.owl @default.
- NCIT_C111794 label "Notch Receptor Intracellular Domain" @default.
- NCIT_C111794 subClassOf B5a3fde5aa12e0d1e5f490fcf6112dcaf @default.
- NCIT_C111794 subClassOf Bd115044e17142e66d6bf4106d590c498 @default.
- NCIT_C111794 subClassOf NCIT_C111794 @default.
- NCIT_C111794 subClassOf NCIT_C26548 @default.
- NCIT_C111794 subClassOf NCIT_C28566 @default.