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- NCIT_C111892 IAO_0000115 "A long-acting formulation of recombinant interferon alpha subtype 2b (IFN-a2b), in which IFN-a2b is coupled, via proline, to polyethylene glycol (PEG), with antiviral, immunomodulating and antineoplastic activities. Upon administration of ropeginterferon alfa-2b, IFN-a2b targets and binds to specific IFN cell-surface receptors. This activates IFN-mediated signal transduction pathways and induces the transcription and translation of genes with IFN-specific response elements (ISREs). Their protein products mediate antiviral, antiproliferative, anticancer, and immune-modulating effects. The PEG moiety inhibits proteolytic breakdown and clearance of IFN-a2b, which prolongs its half-life, extends the duration of its therapeutic effects and allows less frequent dosing. The proline linker facilitates the synthesis of a single positional isomer which further increases its stability and half-life." @default.
- NCIT_C111892 NCIT_A32 NCIT_C1909 @default.
- NCIT_C111892 NCIT_NHC0 "C111892" @default.
- NCIT_C111892 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C111892 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C111892 NCIT_P107 "Ropeginterferon Alfa-2B" @default.
- NCIT_C111892 NCIT_P108 "Ropeginterferon Alfa-2B" @default.
- NCIT_C111892 NCIT_P207 "C3827091" @default.
- NCIT_C111892 NCIT_P210 "1335098-50-4" @default.
- NCIT_C111892 NCIT_P319 "981TME683S" @default.
- NCIT_C111892 NCIT_P322 "CTRP" @default.
- NCIT_C111892 NCIT_P322 "FDA" @default.
- NCIT_C111892 NCIT_P322 "GDC" @default.
- NCIT_C111892 NCIT_P329 "753252" @default.
- NCIT_C111892 NCIT_P330 "753252" @default.
- NCIT_C111892 NCIT_P375 "PEG-Proline-Interferon Alfa-2b" @default.
- NCIT_C111892 NCIT_P375 "Ropeginterferon Alfa-2B" @default.
- NCIT_C111892 NCIT_P399 "753252" @default.
- NCIT_C111892 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C111892 referenceCount "2" @default.
- NCIT_C111892 hasExactSynonym "AOP2014" @default.
- NCIT_C111892 hasExactSynonym "Besremi" @default.
- NCIT_C111892 hasExactSynonym "P-1101" @default.
- NCIT_C111892 hasExactSynonym "P1101" @default.
- NCIT_C111892 hasExactSynonym "PEG-P-IFN-Alfa-2b" @default.
- NCIT_C111892 hasExactSynonym "PEG-P-IFN-Alpha-2b" @default.
- NCIT_C111892 hasExactSynonym "PEG-Proline-Interferon Alfa-2b" @default.
- NCIT_C111892 hasExactSynonym "ROPEGINTERFERON ALFA-2B" @default.
- NCIT_C111892 hasExactSynonym "Ropeginterferon Alfa-2B" @default.
- NCIT_C111892 inSubset NCIT_C116977 @default.
- NCIT_C111892 inSubset NCIT_C116978 @default.
- NCIT_C111892 inSubset NCIT_C128784 @default.
- NCIT_C111892 inSubset NCIT_C157711 @default.
- NCIT_C111892 inSubset NCIT_C157712 @default.
- NCIT_C111892 inSubset NCIT_C176424 @default.
- NCIT_C111892 inSubset NCIT_C177537 @default.
- NCIT_C111892 inSubset NCIT_C63923 @default.
- NCIT_C111892 type Class @default.
- NCIT_C111892 isDefinedBy ncit.owl @default.
- NCIT_C111892 label "Ropeginterferon Alfa-2B" @default.
- NCIT_C111892 subClassOf NCIT_C111892 @default.
- NCIT_C111892 subClassOf NCIT_C1283 @default.
- NCIT_C111892 subClassOf NCIT_C1742 @default.
- NCIT_C111892 subClassOf NCIT_C1845 @default.
- NCIT_C111892 subClassOf NCIT_C1908 @default.
- NCIT_C111892 subClassOf NCIT_C1909 @default.
- NCIT_C111892 subClassOf NCIT_C1971 @default.
- NCIT_C111892 subClassOf NCIT_C225 @default.
- NCIT_C111892 subClassOf NCIT_C2491 @default.
- NCIT_C111892 subClassOf NCIT_C274 @default.
- NCIT_C111892 subClassOf NCIT_C307 @default.
- NCIT_C111892 subClassOf NCIT_C308 @default.
- NCIT_C111892 subClassOf NCIT_C584 @default.