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- NCIT_C111898 IAO_0000115 "An orally bioavailable pan inhibitor of phosphoinositide-3-kinases (PI3K) and inhibitor of the mammalian target of rapamycin (mTOR), with potential antineoplastic activity. Bimiralisib inhibits the PI3K kinase isoforms alpha, beta, gamma and delta and, to a lesser extent, mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to both chemotherapy and radiotherapy. As mTOR, a serine/threonine kinase downstream of PI3K, may also be activated independent of PI3K, this agent may potentially be more potent than an agent that inhibits either PI3K kinase or mTOR kinase. By inhibiting mTOR to a lesser extent than PI3K, PQR309 does not interfere with the mTOR-mediated negative feedback loop on PI3K signaling. Blocking the negative feedback loop would potentially increase PI3K signaling and decrease therapeutic efficacy." @default.
- NCIT_C111898 NCIT_A32 NCIT_C1909 @default.
- NCIT_C111898 NCIT_A7 NCIT_C17270 @default.
- NCIT_C111898 NCIT_NHC0 "C111898" @default.
- NCIT_C111898 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C111898 NCIT_P108 "Bimiralisib" @default.
- NCIT_C111898 NCIT_P208 "CL454230" @default.
- NCIT_C111898 NCIT_P210 "1225037-39-7" @default.
- NCIT_C111898 NCIT_P319 "6Z3QHB00LB" @default.
- NCIT_C111898 NCIT_P322 "FDA" @default.
- NCIT_C111898 NCIT_P322 "GDC" @default.
- NCIT_C111898 NCIT_P329 "753407" @default.
- NCIT_C111898 NCIT_P330 "753407" @default.
- NCIT_C111898 NCIT_P375 "Bimiralisib" @default.
- NCIT_C111898 NCIT_P399 "753407" @default.
- NCIT_C111898 normalizedInformationContent "100" @default.
- NCIT_C111898 referenceCount "1" @default.
- NCIT_C111898 hasExactSynonym "2-Pyridinamine, 5-(4,6-Di-4-morpholinyl-1,3,5-triazin-2-yl)-4-(trifluoromethyl)-" @default.
- NCIT_C111898 hasExactSynonym "BIMIRALISIB" @default.
- NCIT_C111898 hasExactSynonym "Bimiralisib" @default.
- NCIT_C111898 hasExactSynonym "PQR-309" @default.
- NCIT_C111898 hasExactSynonym "PQR309" @default.
- NCIT_C111898 inSubset NCIT_C128784 @default.
- NCIT_C111898 inSubset NCIT_C157711 @default.
- NCIT_C111898 inSubset NCIT_C157712 @default.
- NCIT_C111898 inSubset NCIT_C176424 @default.
- NCIT_C111898 inSubset NCIT_C177537 @default.
- NCIT_C111898 inSubset NCIT_C63923 @default.
- NCIT_C111898 type Class @default.
- NCIT_C111898 isDefinedBy ncit.owl @default.
- NCIT_C111898 label "Bimiralisib" @default.
- NCIT_C111898 subClassOf NCIT_C111898 @default.
- NCIT_C111898 subClassOf NCIT_C129824 @default.
- NCIT_C111898 subClassOf NCIT_C129825 @default.
- NCIT_C111898 subClassOf NCIT_C1404 @default.
- NCIT_C111898 subClassOf NCIT_C163758 @default.
- NCIT_C111898 subClassOf NCIT_C1742 @default.
- NCIT_C111898 subClassOf NCIT_C1908 @default.
- NCIT_C111898 subClassOf NCIT_C1909 @default.
- NCIT_C111898 subClassOf NCIT_C2152 @default.
- NCIT_C111898 subClassOf NCIT_C2189 @default.
- NCIT_C111898 subClassOf NCIT_C274 @default.
- NCIT_C111898 subClassOf NCIT_C471 @default.