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- NCIT_C111901 IAO_0000115 "The anhydrous form of pelabresib, a small molecule inhibitor of the Bromodomain and Extra-Terminal (BET) family of proteins, with potential antineoplastic activity. Upon administration, pelabresib binds to the acetylated lysine recognition motifs on the bromodomain of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histone peptides. This disrupts chromatin remodeling and gene expression. Prevention of the expression of certain growth-promoting genes may lead to an inhibition of tumor cell growth. Characterized by a tandem repeat of two bromodomains at the N-terminus, the BET proteins (BRD2, BRD3, BRD4 and BRDT) are transcriptional regulators that play an important role during development and cellular growth." @default.
- NCIT_C111901 NCIT_A32 NCIT_C1909 @default.
- NCIT_C111901 NCIT_A7 NCIT_C106463 @default.
- NCIT_C111901 NCIT_A7 NCIT_C21376 @default.
- NCIT_C111901 NCIT_A7 NCIT_C92704 @default.
- NCIT_C111901 NCIT_A7 NCIT_C97399 @default.
- NCIT_C111901 NCIT_NHC0 "C111901" @default.
- NCIT_C111901 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C111901 NCIT_P107 "Pelabresib" @default.
- NCIT_C111901 NCIT_P108 "Pelabresib Anhydrous" @default.
- NCIT_C111901 NCIT_P208 "CL454233" @default.
- NCIT_C111901 NCIT_P210 "1380087-89-7" @default.
- NCIT_C111901 NCIT_P319 "U4017GUQ06" @default.
- NCIT_C111901 NCIT_P322 "CTRP" @default.
- NCIT_C111901 NCIT_P322 "FDA" @default.
- NCIT_C111901 NCIT_P322 "GDC" @default.
- NCIT_C111901 NCIT_P329 "753680" @default.
- NCIT_C111901 NCIT_P330 "753680" @default.
- NCIT_C111901 NCIT_P375 "BET Inhibitor CPI-0610" @default.
- NCIT_C111901 NCIT_P375 "Pelabresib" @default.
- NCIT_C111901 NCIT_P399 "753680" @default.
- NCIT_C111901 normalizedInformationContent "100" @default.
- NCIT_C111901 referenceCount "1" @default.
- NCIT_C111901 hasExactSynonym "BET Inhibitor CPI-0610" @default.
- NCIT_C111901 hasExactSynonym "CPI-0610 Anhydrous" @default.
- NCIT_C111901 hasExactSynonym "CPI-232" @default.
- NCIT_C111901 hasExactSynonym "CPI-267232" @default.
- NCIT_C111901 hasExactSynonym "PELABRESIB ANHYDROUS" @default.
- NCIT_C111901 hasExactSynonym "Pelabresib Anhydrous" @default.
- NCIT_C111901 hasExactSynonym "Pelabresib" @default.
- NCIT_C111901 inSubset NCIT_C116977 @default.
- NCIT_C111901 inSubset NCIT_C116978 @default.
- NCIT_C111901 inSubset NCIT_C128784 @default.
- NCIT_C111901 inSubset NCIT_C157711 @default.
- NCIT_C111901 inSubset NCIT_C157712 @default.
- NCIT_C111901 inSubset NCIT_C176424 @default.
- NCIT_C111901 inSubset NCIT_C177537 @default.
- NCIT_C111901 inSubset NCIT_C63923 @default.
- NCIT_C111901 type Class @default.
- NCIT_C111901 isDefinedBy ncit.owl @default.
- NCIT_C111901 label "Pelabresib Anhydrous" @default.
- NCIT_C111901 subClassOf NCIT_C111901 @default.
- NCIT_C111901 subClassOf NCIT_C128462 @default.
- NCIT_C111901 subClassOf NCIT_C129824 @default.
- NCIT_C111901 subClassOf NCIT_C1908 @default.
- NCIT_C111901 subClassOf NCIT_C1909 @default.
- NCIT_C111901 subClassOf NCIT_C2189 @default.
- NCIT_C111901 subClassOf NCIT_C274 @default.