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- NCIT_C111903 IAO_0000115 "A poloxamer-formulated, bivalent DNA vaccine containing two plasmids encoding both the human cytomegaloviral (CMV) tegument phosphoprotein 65 (pp65), a major internal matrix protein, and glycoprotein B (gB), an important CMV component responsible for attachment and entry into cells, with potential immunostimulatory properties. Upon intramuscular injection of CMVpp65/gB plasmid vaccine ASP0113, the expressed proteins may activate the immune system to mount both cellular and humoral immune responses against CMV-positive cells. This results in cell lysis of CMV-infected cells and prevents both viral replication and the development of CMV disease. This vaccine also provides active immunization and protective immunity against CMV infection in CMV-negative patients exposed to infected donor cells or tissues in transplant recipients. CMV infection can cause serious complications in patients receiving either allogeneic hematopoietic cell transplants (HCT) or solid organ transplants. The poloxamer-based delivery system enhances DNA delivery." @default.
- NCIT_C111903 NCIT_A7 NCIT_C141213 @default.
- NCIT_C111903 NCIT_NHC0 "C111903" @default.
- NCIT_C111903 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C111903 NCIT_P107 "CMVpp65/gB Plasmid Vaccine ASP0113" @default.
- NCIT_C111903 NCIT_P108 "CMVpp65/gB Plasmid Vaccine ASP0113" @default.
- NCIT_C111903 NCIT_P208 "CL454235" @default.
- NCIT_C111903 NCIT_P322 "CTRP" @default.
- NCIT_C111903 NCIT_P329 "753682" @default.
- NCIT_C111903 NCIT_P330 "753682" @default.
- NCIT_C111903 NCIT_P399 "753682" @default.
- NCIT_C111903 normalizedInformationContent "100" @default.
- NCIT_C111903 referenceCount "1" @default.
- NCIT_C111903 hasExactSynonym "ASP0113" @default.
- NCIT_C111903 hasExactSynonym "CMVpp65/gB Plasmid Vaccine ASP0113" @default.
- NCIT_C111903 hasExactSynonym "TransVax" @default.
- NCIT_C111903 inSubset NCIT_C116977 @default.
- NCIT_C111903 inSubset NCIT_C116978 @default.
- NCIT_C111903 inSubset NCIT_C176424 @default.
- NCIT_C111903 type Class @default.
- NCIT_C111903 isDefinedBy ncit.owl @default.
- NCIT_C111903 label "CMVpp65/gB Plasmid Vaccine ASP0113" @default.
- NCIT_C111903 subClassOf NCIT_C111903 @default.
- NCIT_C111903 subClassOf NCIT_C1908 @default.
- NCIT_C111903 subClassOf NCIT_C1909 @default.
- NCIT_C111903 subClassOf NCIT_C307 @default.
- NCIT_C111903 subClassOf NCIT_C308 @default.
- NCIT_C111903 subClassOf NCIT_C39619 @default.
- NCIT_C111903 subClassOf NCIT_C923 @default.