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- NCIT_C111906 IAO_0000115 "A targeted antibody payload (TAP)-based immunoconjugate consisting of a human monoclonal antibody directed against the epidermal growth factor receptor (EGFR) conjugated, via a nonreducible thioether linker (succinimidyl trans-4-(maleimidylmethyl)cyclohexane-1-carboxylate or SMCC), to the cytotoxic agent maytansinoid mertansine (DM1), with potential antineoplastic activity. Upon intravenous administration, the monoclonal antibody moiety of laprituximab emtansine binds to and inhibits EGFR on tumor cell surfaces. Inhibition of EGFR prevents EGFR-mediated signaling and may inhibit tumor cell proliferation. After internalization, the mertansine moiety binds to tubulin and interferes with microtubule assembly/disassembly dynamics. This inhibits both cell division and the proliferation of cancer cells that express EGFR. EGFR, overexpressed by a variety of cancers, plays a key role in tumor cell proliferation and survival. Linkage of the antibody and drug, through a nonreducible linker, appears to contribute to the improved efficacy and reduced toxicity of this antibody-drug conjugate (ADC) compared to similar ADCs constructed with reducible linkers." @default.
- NCIT_C111906 NCIT_A32 NCIT_C1909 @default.
- NCIT_C111906 NCIT_A7 NCIT_C17068 @default.
- NCIT_C111906 NCIT_NHC0 "C111906" @default.
- NCIT_C111906 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C111906 NCIT_P107 "Laprituximab Emtansine" @default.
- NCIT_C111906 NCIT_P108 "Laprituximab Emtansine" @default.
- NCIT_C111906 NCIT_P208 "CL454236" @default.
- NCIT_C111906 NCIT_P210 "1622327-37-0" @default.
- NCIT_C111906 NCIT_P319 "7J0LQD86OG" @default.
- NCIT_C111906 NCIT_P322 "CTRP" @default.
- NCIT_C111906 NCIT_P322 "FDA" @default.
- NCIT_C111906 NCIT_P322 "GDC" @default.
- NCIT_C111906 NCIT_P329 "753683" @default.
- NCIT_C111906 NCIT_P330 "753683" @default.
- NCIT_C111906 NCIT_P375 "Anti-EGFR TAP Antibody-drug Conjugate IMGN289" @default.
- NCIT_C111906 NCIT_P375 "Laprituximab Emtansine" @default.
- NCIT_C111906 NCIT_P399 "753683" @default.
- NCIT_C111906 normalizedInformationContent "100" @default.
- NCIT_C111906 referenceCount "1" @default.
- NCIT_C111906 hasExactSynonym "Anti-EGFR-SMCC-DM1" @default.
- NCIT_C111906 hasExactSynonym "IMGN289" @default.
- NCIT_C111906 hasExactSynonym "LAPRITUXIMAB EMTANSINE" @default.
- NCIT_C111906 hasExactSynonym "Laprituximab Emtansine" @default.
- NCIT_C111906 inSubset NCIT_C116977 @default.
- NCIT_C111906 inSubset NCIT_C116978 @default.
- NCIT_C111906 inSubset NCIT_C128784 @default.
- NCIT_C111906 inSubset NCIT_C157711 @default.
- NCIT_C111906 inSubset NCIT_C157712 @default.
- NCIT_C111906 inSubset NCIT_C176424 @default.
- NCIT_C111906 inSubset NCIT_C177537 @default.
- NCIT_C111906 inSubset NCIT_C63923 @default.
- NCIT_C111906 type Class @default.
- NCIT_C111906 isDefinedBy ncit.owl @default.
- NCIT_C111906 label "Laprituximab Emtansine" @default.
- NCIT_C111906 subClassOf NCIT_C111906 @default.
- NCIT_C111906 subClassOf NCIT_C129821 @default.
- NCIT_C111906 subClassOf NCIT_C129823 @default.
- NCIT_C111906 subClassOf NCIT_C1512 @default.
- NCIT_C111906 subClassOf NCIT_C163758 @default.
- NCIT_C111906 subClassOf NCIT_C163952 @default.
- NCIT_C111906 subClassOf NCIT_C1908 @default.
- NCIT_C111906 subClassOf NCIT_C1909 @default.
- NCIT_C111906 subClassOf NCIT_C201551 @default.
- NCIT_C111906 subClassOf NCIT_C274 @default.
- NCIT_C111906 subClassOf NCIT_C307 @default.
- NCIT_C111906 subClassOf NCIT_C308 @default.