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- NCIT_C111990 IAO_0000115 "An orally available fumarate salt form of CFI-400945, a polo-like kinase 4 (PLK4) inhibitor with potential antineoplastic activity. Upon oral administration, polo-like kinase 4 inhibitor CFI-400945 selectively inhibits PLK4, which results in the disruption of mitosis and the induction of apoptosis. PLK4 inhibition also prevents cell division and inhibits proliferation of PLK4-overexpressing tumor cells. PLK4, a member of the polo family of serine/threonine kinases overexpressed in a variety of cancer cell types, plays a crucial role in the regulation of centriole duplication during the cell cycle." @default.
- NCIT_C111990 NCIT_A32 NCIT_C1909 @default.
- NCIT_C111990 NCIT_A6 NCIT_C185146 @default.
- NCIT_C111990 NCIT_NHC0 "C111990" @default.
- NCIT_C111990 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C111990 NCIT_P108 "Ocifisertib Fumarate" @default.
- NCIT_C111990 NCIT_P208 "CL454279" @default.
- NCIT_C111990 NCIT_P210 "1616420-30-4" @default.
- NCIT_C111990 NCIT_P319 "09OB3E5QTD" @default.
- NCIT_C111990 NCIT_P322 "FDA" @default.
- NCIT_C111990 NCIT_P322 "GDC" @default.
- NCIT_C111990 NCIT_P329 "754001" @default.
- NCIT_C111990 NCIT_P330 "754001" @default.
- NCIT_C111990 NCIT_P375 "Polo-like Kinase 4 Inhibitor CFI-400945 Fumarate" @default.
- NCIT_C111990 NCIT_P399 "754001" @default.
- NCIT_C111990 normalizedInformationContent "100" @default.
- NCIT_C111990 referenceCount "1" @default.
- NCIT_C111990 hasExactSynonym "CFI 400945 Fumarate" @default.
- NCIT_C111990 hasExactSynonym "CFI-400945 Fumarate" @default.
- NCIT_C111990 hasExactSynonym "CFI-400945" @default.
- NCIT_C111990 hasExactSynonym "OCIFISERTIB FUMARATE" @default.
- NCIT_C111990 hasExactSynonym "Ocifisertib Fumarate" @default.
- NCIT_C111990 hasExactSynonym "PLK4 Inhibitor CFI-400945 Fumarate" @default.
- NCIT_C111990 hasExactSynonym "Polo-like Kinase 4 Inhibitor CFI-400945 Fumarate" @default.
- NCIT_C111990 inSubset NCIT_C128784 @default.
- NCIT_C111990 inSubset NCIT_C157711 @default.
- NCIT_C111990 inSubset NCIT_C157712 @default.
- NCIT_C111990 inSubset NCIT_C176424 @default.
- NCIT_C111990 inSubset NCIT_C177537 @default.
- NCIT_C111990 inSubset NCIT_C63923 @default.
- NCIT_C111990 type Class @default.
- NCIT_C111990 isDefinedBy ncit.owl @default.
- NCIT_C111990 label "Ocifisertib Fumarate" @default.
- NCIT_C111990 subClassOf NCIT_C111990 @default.
- NCIT_C111990 subClassOf NCIT_C129824 @default.
- NCIT_C111990 subClassOf NCIT_C129825 @default.
- NCIT_C111990 subClassOf NCIT_C1404 @default.
- NCIT_C111990 subClassOf NCIT_C1908 @default.
- NCIT_C111990 subClassOf NCIT_C1909 @default.
- NCIT_C111990 subClassOf NCIT_C2189 @default.
- NCIT_C111990 subClassOf NCIT_C274 @default.
- NCIT_C111990 subClassOf NCIT_C471 @default.
- NCIT_C111990 subClassOf NCIT_C61074 @default.