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- NCIT_C111992 IAO_0000115 "A preparation of tumor infiltrating lymphocytes (TILs) that are transduced with a retroviral vector encoding a gene for a dominant-negative form of the transforming growth factor beta (TGFb) receptor, TGFbDNRII, with potential immunomodulating activity. Upon administration, the TGFbDNRII-transduced autologous TILs recognize and kill tumor cells. The expression of TGFbDNRII allows for the TILs to be resistant to TGF-b-mediated inhibition of T cell proliferation and activation, which allows optimal TIL activity. The immunosuppressant TGF-b is produced by tumor cells and plays a key role in the repression of the immune system." @default.
- NCIT_C111992 NCIT_NHC0 "C111992" @default.
- NCIT_C111992 NCIT_P106 "Cell" @default.
- NCIT_C111992 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C111992 NCIT_P108 "TGFbDNRII-transduced Autologous Tumor Infiltrating Lymphocytes" @default.
- NCIT_C111992 NCIT_P208 "CL454281" @default.
- NCIT_C111992 NCIT_P329 "754014" @default.
- NCIT_C111992 NCIT_P330 "754014" @default.
- NCIT_C111992 NCIT_P399 "754014" @default.
- NCIT_C111992 NCIT_R124 NCIT_C17828 @default.
- NCIT_C111992 NCIT_R124 NCIT_C17930 @default.
- NCIT_C111992 NCIT_R124 NCIT_C17937 @default.
- NCIT_C111992 NCIT_R124 NCIT_C18839 @default.
- NCIT_C111992 NCIT_R124 NCIT_C21124 @default.
- NCIT_C111992 NCIT_R124 NCIT_C45548 @default.
- NCIT_C111992 NCIT_R125 NCIT_C17828 @default.
- NCIT_C111992 NCIT_R125 NCIT_C17937 @default.
- NCIT_C111992 NCIT_R125 NCIT_C18095 @default.
- NCIT_C111992 NCIT_R125 NCIT_C18839 @default.
- NCIT_C111992 NCIT_R125 NCIT_C19053 @default.
- NCIT_C111992 NCIT_R125 NCIT_C21124 @default.
- NCIT_C111992 NCIT_R125 NCIT_C26280 @default.
- NCIT_C111992 NCIT_R125 NCIT_C40833 @default.
- NCIT_C111992 NCIT_R125 NCIT_C40912 @default.
- NCIT_C111992 NCIT_R72 NCIT_C104083 @default.
- NCIT_C111992 NCIT_R72 NCIT_C12219 @default.
- NCIT_C111992 NCIT_R72 NCIT_C12476 @default.
- NCIT_C111992 NCIT_R72 NCIT_C12508 @default.
- NCIT_C111992 NCIT_R72 NCIT_C12535 @default.
- NCIT_C111992 NCIT_R72 NCIT_C12542 @default.
- NCIT_C111992 NCIT_R72 NCIT_C12543 @default.
- NCIT_C111992 NCIT_R72 NCIT_C21599 @default.
- NCIT_C111992 NCIT_R72 NCIT_C32725 @default.
- NCIT_C111992 NCIT_R72 NCIT_C33061 @default.
- NCIT_C111992 NCIT_R72 NCIT_C38434 @default.
- NCIT_C111992 NCIT_R72 NCIT_C38439 @default.
- NCIT_C111992 NCIT_R72 NCIT_C39567 @default.
- NCIT_C111992 NCIT_R72 NCIT_C39568 @default.
- NCIT_C111992 normalizedInformationContent "100" @default.
- NCIT_C111992 referenceCount "1" @default.
- NCIT_C111992 hasExactSynonym "TGFbDNRII-transduced Autologous TILs" @default.
- NCIT_C111992 hasExactSynonym "TGFbDNRII-transduced Autologous Tumor Infiltrating Lymphocytes" @default.
- NCIT_C111992 inSubset NCIT_C128784 @default.
- NCIT_C111992 inSubset NCIT_C176424 @default.
- NCIT_C111992 type Class @default.
- NCIT_C111992 isDefinedBy ncit.owl @default.
- NCIT_C111992 label "TGFbDNRII-transduced Autologous Tumor Infiltrating Lymphocytes" @default.
- NCIT_C111992 subClassOf NCIT_C111992 @default.
- NCIT_C111992 subClassOf NCIT_C129820 @default.
- NCIT_C111992 subClassOf NCIT_C129821 @default.
- NCIT_C111992 subClassOf NCIT_C129826 @default.
- NCIT_C111992 subClassOf NCIT_C142078 @default.
- NCIT_C111992 subClassOf NCIT_C154231 @default.
- NCIT_C111992 subClassOf NCIT_C1908 @default.
- NCIT_C111992 subClassOf NCIT_C1909 @default.
- NCIT_C111992 subClassOf NCIT_C1962 @default.
- NCIT_C111992 subClassOf NCIT_C201547 @default.
- NCIT_C111992 subClassOf NCIT_C274 @default.
- NCIT_C111992 subClassOf NCIT_C28681 @default.
- NCIT_C111992 subClassOf NCIT_C307 @default.
- NCIT_C111992 subClassOf NCIT_C308 @default.