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- NCIT_C111993 IAO_0000115 "An orally available morpholino-pyrimidine-based inhibitor of ataxia telangiectasia and rad3 related (ATR) kinase, with potential antineoplastic activity. Upon oral administration, Ceralasertib selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine protein kinase CHK1. This prevents ATR-mediated signaling, and results in the inhibition of DNA damage checkpoint activation, disruption of DNA damage repair, and the induction of tumor cell apoptosis. In addition, AZD6738 sensitizes tumor cells to chemo- and radiotherapy. ATR, a serine/threonine protein kinase upregulated in a variety of cancer cell types, plays a key role in DNA repair, cell cycle progression and survival; it is activated by DNA damage caused during DNA replication-associated stress." @default.
- NCIT_C111993 NCIT_A32 NCIT_C1909 @default.
- NCIT_C111993 NCIT_A7 NCIT_C21430 @default.
- NCIT_C111993 NCIT_A7 NCIT_C25919 @default.
- NCIT_C111993 NCIT_NHC0 "C111993" @default.
- NCIT_C111993 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C111993 NCIT_P107 "Ceralasertib" @default.
- NCIT_C111993 NCIT_P108 "Ceralasertib" @default.
- NCIT_C111993 NCIT_P208 "CL454282" @default.
- NCIT_C111993 NCIT_P210 "1352226-88-0" @default.
- NCIT_C111993 NCIT_P319 "85RE35306Z" @default.
- NCIT_C111993 NCIT_P322 "CTRP" @default.
- NCIT_C111993 NCIT_P322 "FDA" @default.
- NCIT_C111993 NCIT_P322 "GDC" @default.
- NCIT_C111993 NCIT_P329 "754022" @default.
- NCIT_C111993 NCIT_P330 "754022" @default.
- NCIT_C111993 NCIT_P375 "Ceralasertib" @default.
- NCIT_C111993 NCIT_P399 "754022" @default.
- NCIT_C111993 normalizedInformationContent "100" @default.
- NCIT_C111993 referenceCount "1" @default.
- NCIT_C111993 hasExactSynonym "AZD6738" @default.
- NCIT_C111993 hasExactSynonym "CERALASERTIB" @default.
- NCIT_C111993 hasExactSynonym "Ceralasertib" @default.
- NCIT_C111993 inSubset NCIT_C116977 @default.
- NCIT_C111993 inSubset NCIT_C116978 @default.
- NCIT_C111993 inSubset NCIT_C128784 @default.
- NCIT_C111993 inSubset NCIT_C157711 @default.
- NCIT_C111993 inSubset NCIT_C157712 @default.
- NCIT_C111993 inSubset NCIT_C176424 @default.
- NCIT_C111993 inSubset NCIT_C177537 @default.
- NCIT_C111993 inSubset NCIT_C63923 @default.
- NCIT_C111993 type Class @default.
- NCIT_C111993 isDefinedBy ncit.owl @default.
- NCIT_C111993 label "Ceralasertib" @default.
- NCIT_C111993 subClassOf NCIT_C111993 @default.
- NCIT_C111993 subClassOf NCIT_C129824 @default.
- NCIT_C111993 subClassOf NCIT_C129825 @default.
- NCIT_C111993 subClassOf NCIT_C1404 @default.
- NCIT_C111993 subClassOf NCIT_C155926 @default.
- NCIT_C111993 subClassOf NCIT_C1908 @default.
- NCIT_C111993 subClassOf NCIT_C1909 @default.
- NCIT_C111993 subClassOf NCIT_C2189 @default.
- NCIT_C111993 subClassOf NCIT_C274 @default.
- NCIT_C111993 subClassOf NCIT_C471 @default.
- NCIT_C111993 subClassOf NCIT_C61074 @default.