Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C111994> ?p ?o ?g. }
Showing items 1 to 31 of
31
with 100 items per page.
- NCIT_C111994 IAO_0000115 "An inhibitor of the adenosine triphosphate (ATP)-binding cassette (ABC) transporter P-glycoprotein (P-gp), with adjuvant activity. Upon oral administration, encequidar selectively binds to and inhibits the multidrug resistance (MDR) efflux pump P-gp, which prevents the efflux of various chemotherapeutic agents from intestinal epithelial cells to the gastrointestinal tract. This leads to an increase in both oral bioavailability and therapeutic efficacy. P-gp prevents the intestinal uptake and intracellular accumulation of various cytotoxic agents. Encequidar is not systemically absorbed." @default.
- NCIT_C111994 NCIT_NHC0 "C111994" @default.
- NCIT_C111994 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C111994 NCIT_P107 "Encequidar" @default.
- NCIT_C111994 NCIT_P108 "Encequidar" @default.
- NCIT_C111994 NCIT_P208 "CL454283" @default.
- NCIT_C111994 NCIT_P210 "849675-66-7" @default.
- NCIT_C111994 NCIT_P319 "K4I4I996O4" @default.
- NCIT_C111994 NCIT_P322 "CTRP" @default.
- NCIT_C111994 NCIT_P322 "FDA" @default.
- NCIT_C111994 NCIT_P329 "754065" @default.
- NCIT_C111994 NCIT_P330 "754065" @default.
- NCIT_C111994 NCIT_P399 "754065" @default.
- NCIT_C111994 normalizedInformationContent "100" @default.
- NCIT_C111994 referenceCount "1" @default.
- NCIT_C111994 hasExactSynonym "4-Oxo-4H-chromene-2-carboxylic acid [2-(2-4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-phenyl-2H-tetrazol-5-yl)-4,5-dimethoxy-phenyl]-amide" @default.
- NCIT_C111994 hasExactSynonym "ENCEQUIDAR" @default.
- NCIT_C111994 hasExactSynonym "Encequidar" @default.
- NCIT_C111994 hasExactSynonym "HM30181AK" @default.
- NCIT_C111994 hasExactSynonym "Pgp Inhibitor HM30181AK" @default.
- NCIT_C111994 inSubset NCIT_C116977 @default.
- NCIT_C111994 inSubset NCIT_C116978 @default.
- NCIT_C111994 inSubset NCIT_C176424 @default.
- NCIT_C111994 inSubset NCIT_C63923 @default.
- NCIT_C111994 type Class @default.
- NCIT_C111994 isDefinedBy ncit.owl @default.
- NCIT_C111994 label "Encequidar" @default.
- NCIT_C111994 subClassOf NCIT_C111994 @default.
- NCIT_C111994 subClassOf NCIT_C1908 @default.
- NCIT_C111994 subClassOf NCIT_C1909 @default.
- NCIT_C111994 subClassOf NCIT_C2140 @default.