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- NCIT_C112000 IAO_0000115 "A combination formulation composed of a capsule containing the taxane compound paclitaxel and a tablet containing the multidrug resistance (MDR) efflux pump P-glycoprotein (P-gp) inhibitor HM30181A, with potential antineoplastic activity. Upon oral administration of oraxol, the HM30181A moiety binds to and inhibits P-gp, which prevents P-gp-mediated efflux of paclitaxel, therefore enhancing its oral bioavailability. In turn, paclitaxel binds to and stabilizes microtubules, preventing their depolymerization, which results in the inhibition of cellular motility, mitosis, and replication. Altogether, this may result in greater intracellular concentration of paclitaxel, and enhanced cytotoxicity against tumor cells, when compared to the administration of paclitaxel alone. P-gp, encoded by the MDR-1 gene, is a member of the ATP-binding cassette (ABC) superfamily of transmembrane transporters; it prevents the intestinal uptake and intracellular accumulation of various cytotoxic agents." @default.
- NCIT_C112000 NCIT_A32 NCIT_C1909 @default.
- NCIT_C112000 NCIT_A7 NCIT_C17219 @default.
- NCIT_C112000 NCIT_A7 NCIT_C18115 @default.
- NCIT_C112000 NCIT_NHC0 "C112000" @default.
- NCIT_C112000 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C112000 NCIT_P107 "Oraxol" @default.
- NCIT_C112000 NCIT_P108 "Oraxol" @default.
- NCIT_C112000 NCIT_P208 "CL454289" @default.
- NCIT_C112000 NCIT_P322 "CTRP" @default.
- NCIT_C112000 NCIT_P322 "GDC" @default.
- NCIT_C112000 NCIT_P329 "754236" @default.
- NCIT_C112000 NCIT_P330 "754236" @default.
- NCIT_C112000 NCIT_P375 "Oraxol" @default.
- NCIT_C112000 NCIT_P399 "754236" @default.
- NCIT_C112000 NCIT_R124 NCIT_C17828 @default.
- NCIT_C112000 NCIT_R124 NCIT_C20480 @default.
- NCIT_C112000 NCIT_R124 NCIT_C40795 @default.
- NCIT_C112000 NCIT_R124 NCIT_C40798 @default.
- NCIT_C112000 normalizedInformationContent "100" @default.
- NCIT_C112000 referenceCount "1" @default.
- NCIT_C112000 hasExactSynonym "Oraxol" @default.
- NCIT_C112000 hasExactSynonym "Paclitaxel-HM30181 Methanesulfonate Monohydrate" @default.
- NCIT_C112000 hasExactSynonym "Paclitaxel/HM30181A" @default.
- NCIT_C112000 inSubset NCIT_C116977 @default.
- NCIT_C112000 inSubset NCIT_C116978 @default.
- NCIT_C112000 inSubset NCIT_C128784 @default.
- NCIT_C112000 inSubset NCIT_C157711 @default.
- NCIT_C112000 inSubset NCIT_C157712 @default.
- NCIT_C112000 inSubset NCIT_C176424 @default.
- NCIT_C112000 inSubset NCIT_C177537 @default.
- NCIT_C112000 type Class @default.
- NCIT_C112000 isDefinedBy ncit.owl @default.
- NCIT_C112000 label "Oraxol" @default.
- NCIT_C112000 subClassOf NCIT_C112000 @default.
- NCIT_C112000 subClassOf NCIT_C186664 @default.
- NCIT_C112000 subClassOf NCIT_C1908 @default.
- NCIT_C112000 subClassOf NCIT_C1909 @default.
- NCIT_C112000 subClassOf NCIT_C25974 @default.
- NCIT_C112000 subClassOf NCIT_C273 @default.
- NCIT_C112000 subClassOf NCIT_C274 @default.
- NCIT_C112000 subClassOf NCIT_C61078 @default.
- NCIT_C112000 subClassOf NCIT_C67437 @default.