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- NCIT_C112001 IAO_0000115 "An antibody-drug conjugate (ADC) composed of a humanized monoclonal antibody directed against the anti-solute carrier family 39 zinc transporter member 6 (SLC39A6; LIV-1; ZIP6) protein that is conjugated, via a protease-cleavable linker, to the cytotoxic agent monomethyl auristatin E (MMAE), with potential antineoplastic activity. Upon administration and internalization by LIV-1-positive tumor cells, ladiratuzumab vedotin undergoes enzymatic cleavage to release MMAE into the cytosol. In turn, MMAE binds to and inhibits tubulin polymerization, which may result in G2/M phase cell cycle arrest and apoptosis in LIV-1-expressing tumor cells. LIV-1, a member of the zinc transporter family, is expressed in several types of solid tumors and plays a key role in tumor cell progression and metastasis. The linkage system in ladiratuzumab vedotin is highly stable in plasma, resulting in cytotoxic specificity against LIV-1-positive cells." @default.
- NCIT_C112001 NCIT_A32 NCIT_C1909 @default.
- NCIT_C112001 NCIT_A7 NCIT_C125525 @default.
- NCIT_C112001 NCIT_NHC0 "C112001" @default.
- NCIT_C112001 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C112001 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C112001 NCIT_P107 "Ladiratuzumab Vedotin" @default.
- NCIT_C112001 NCIT_P108 "Ladiratuzumab Vedotin" @default.
- NCIT_C112001 NCIT_P207 "C3827076" @default.
- NCIT_C112001 NCIT_P210 "1629760-29-7" @default.
- NCIT_C112001 NCIT_P319 "VM4G5D1A60" @default.
- NCIT_C112001 NCIT_P322 "CTRP" @default.
- NCIT_C112001 NCIT_P322 "FDA" @default.
- NCIT_C112001 NCIT_P322 "GDC" @default.
- NCIT_C112001 NCIT_P329 "754237" @default.
- NCIT_C112001 NCIT_P330 "754237" @default.
- NCIT_C112001 NCIT_P375 "Anti-LIV-1 Monoclonal Antibody-MMAE Conjugate SGN-LIV1A" @default.
- NCIT_C112001 NCIT_P375 "Ladiratuzumab Vedotin" @default.
- NCIT_C112001 NCIT_P399 "754237" @default.
- NCIT_C112001 normalizedInformationContent "100" @default.
- NCIT_C112001 referenceCount "1" @default.
- NCIT_C112001 hasExactSynonym "LADIRATUZUMAB VEDOTIN" @default.
- NCIT_C112001 hasExactSynonym "Ladiratuzumab Vedotin" @default.
- NCIT_C112001 hasExactSynonym "SGN-LIV1A" @default.
- NCIT_C112001 inSubset NCIT_C116977 @default.
- NCIT_C112001 inSubset NCIT_C116978 @default.
- NCIT_C112001 inSubset NCIT_C128784 @default.
- NCIT_C112001 inSubset NCIT_C157711 @default.
- NCIT_C112001 inSubset NCIT_C157712 @default.
- NCIT_C112001 inSubset NCIT_C176424 @default.
- NCIT_C112001 inSubset NCIT_C177537 @default.
- NCIT_C112001 inSubset NCIT_C63923 @default.
- NCIT_C112001 type Class @default.
- NCIT_C112001 isDefinedBy ncit.owl @default.
- NCIT_C112001 label "Ladiratuzumab Vedotin" @default.
- NCIT_C112001 subClassOf NCIT_C112001 @default.
- NCIT_C112001 subClassOf NCIT_C129821 @default.
- NCIT_C112001 subClassOf NCIT_C129823 @default.
- NCIT_C112001 subClassOf NCIT_C1512 @default.
- NCIT_C112001 subClassOf NCIT_C1908 @default.
- NCIT_C112001 subClassOf NCIT_C1909 @default.
- NCIT_C112001 subClassOf NCIT_C274 @default.
- NCIT_C112001 subClassOf NCIT_C307 @default.
- NCIT_C112001 subClassOf NCIT_C308 @default.