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- NCIT_C112002 IAO_0000115 "An orally available benzenoid that acts as an opioid peptide receptor agonist for the nociceptin/orphanin FQ peptide receptor (opioid receptor like -1; OPRL1; ORL-1; NOP; kappa-type 3 opioid receptor) and the classical opioid receptors, mu, delta and kappa, with potential anti-nociceptive activity. Upon oral administration, cebranopadol binds to NOP and the mu, delta and kappa opioid receptors, which enhances NOP- and opioid receptor-mediated signaling, interferes with the sensation of pain and results in an analgesic effect. NOP, a member of the opioid receptor family, and its endogenous ligand nociceptin play key roles in the regulation of various brain activities including pain, and some inflammatory and immune responses." @default.
- NCIT_C112002 NCIT_NHC0 "C112002" @default.
- NCIT_C112002 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C112002 NCIT_P108 "Cebranopadol" @default.
- NCIT_C112002 NCIT_P207 "C3827125" @default.
- NCIT_C112002 NCIT_P210 "863513-91-1" @default.
- NCIT_C112002 NCIT_P319 "7GDW9S3GN3" @default.
- NCIT_C112002 NCIT_P322 "FDA" @default.
- NCIT_C112002 NCIT_P329 "754238" @default.
- NCIT_C112002 NCIT_P330 "754238" @default.
- NCIT_C112002 NCIT_P399 "754238" @default.
- NCIT_C112002 normalizedInformationContent "100" @default.
- NCIT_C112002 referenceCount "1" @default.
- NCIT_C112002 hasExactSynonym "CEBRANOPADOL" @default.
- NCIT_C112002 hasExactSynonym "Cebranopadol" @default.
- NCIT_C112002 hasExactSynonym "GRT 6005" @default.
- NCIT_C112002 hasExactSynonym "GRT-6005" @default.
- NCIT_C112002 hasExactSynonym "GRT6005" @default.
- NCIT_C112002 hasExactSynonym "Spiro[cyclohexane-1,1'(3'H)-pyrano[3,4-b]indol]-4-amine, 6'-fluoro-4',9'-dihydro-N,N-dimethyl-4-phenyl-, (1alpha,4beta)-" @default.
- NCIT_C112002 inSubset NCIT_C176424 @default.
- NCIT_C112002 inSubset NCIT_C63923 @default.
- NCIT_C112002 type Class @default.
- NCIT_C112002 isDefinedBy ncit.owl @default.
- NCIT_C112002 label "Cebranopadol" @default.
- NCIT_C112002 subClassOf NCIT_C112002 @default.
- NCIT_C112002 subClassOf NCIT_C1908 @default.
- NCIT_C112002 subClassOf NCIT_C1909 @default.
- NCIT_C112002 subClassOf NCIT_C241 @default.
- NCIT_C112002 subClassOf NCIT_C78272 @default.