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- NCIT_C112003 IAO_0000115 "A peptide-based melanoma cancer vaccine consisting of neoantigens and peptides derived from patient-specific melanoma immunogenic epitopes, combined with the immunostimulant poly-ICLC with potential immunomodulating and antineoplastic activities. Vaccination with the neoantigen-based melanoma vaccine stimulates the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells expressing the neoantigens, which results in tumor cell lysis. The adjuvant poly-ICLC, composed of double-stranded RNA molecules of polyinosinic-polycytidylic acid stabilized with poly L-lysine in carboxymethylcellulose, is a ligand for toll-like receptor-3 (TLR3) and induces the release of cytokines which may help to boost the immune response against the selected neoantigens." @default.
- NCIT_C112003 NCIT_A32 NCIT_C1909 @default.
- NCIT_C112003 NCIT_NHC0 "C112003" @default.
- NCIT_C112003 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C112003 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C112003 NCIT_P108 "Neoantigen-based Melanoma-Poly-ICLC Vaccine" @default.
- NCIT_C112003 NCIT_P208 "CL454292" @default.
- NCIT_C112003 NCIT_P322 "GDC" @default.
- NCIT_C112003 NCIT_P329 "754239" @default.
- NCIT_C112003 NCIT_P330 "754239" @default.
- NCIT_C112003 NCIT_P375 "Neoantigen-based Melanoma-Poly-ICLC Vaccine" @default.
- NCIT_C112003 NCIT_P399 "754239" @default.
- NCIT_C112003 normalizedInformationContent "100" @default.
- NCIT_C112003 referenceCount "1" @default.
- NCIT_C112003 hasExactSynonym "NeoVax Melanoma Vaccine" @default.
- NCIT_C112003 hasExactSynonym "Neoantigen-based Melanoma-Poly-ICLC Vaccine" @default.
- NCIT_C112003 inSubset NCIT_C128784 @default.
- NCIT_C112003 inSubset NCIT_C157711 @default.
- NCIT_C112003 inSubset NCIT_C157712 @default.
- NCIT_C112003 inSubset NCIT_C176424 @default.
- NCIT_C112003 inSubset NCIT_C177537 @default.
- NCIT_C112003 type Class @default.
- NCIT_C112003 isDefinedBy ncit.owl @default.
- NCIT_C112003 label "Neoantigen-based Melanoma-Poly-ICLC Vaccine" @default.
- NCIT_C112003 subClassOf NCIT_C112003 @default.
- NCIT_C112003 subClassOf NCIT_C129820 @default.
- NCIT_C112003 subClassOf NCIT_C1663 @default.
- NCIT_C112003 subClassOf NCIT_C1908 @default.
- NCIT_C112003 subClassOf NCIT_C1909 @default.
- NCIT_C112003 subClassOf NCIT_C2517 @default.
- NCIT_C112003 subClassOf NCIT_C274 @default.
- NCIT_C112003 subClassOf NCIT_C307 @default.
- NCIT_C112003 subClassOf NCIT_C308 @default.
- NCIT_C112003 subClassOf NCIT_C923 @default.