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- NCIT_C112004 IAO_0000115 "An orally available inhibitor of the serine/threonine protein kinases ribosomal protein S6 Kinase (p70S6K) and Akt (protein kinase B), with potential antineoplastic activity. Upon administration, p70S6K/Akt inhibitor M-2698 binds to and inhibits the activity of p70S6K and Akt. This prevents the activation of the PI3K/Akt/p70S6K signaling pathway and inhibits tumor cell proliferation in cancer cells that have an overactivated PI3K/Akt/p70S6K signaling pathway. Constitutive activation and dysregulated signaling of the PI3K/Akt/p70S6K pathway are frequently associated with tumorigenesis of many tumor types; targeting multiple kinases in this pathway is more efficacious than targeting a single kinase." @default.
- NCIT_C112004 NCIT_A32 NCIT_C1909 @default.
- NCIT_C112004 NCIT_NHC0 "C112004" @default.
- NCIT_C112004 NCIT_P106 "Organic Chemical" @default.
- NCIT_C112004 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C112004 NCIT_P107 "p70S6K/Akt Inhibitor M-2698" @default.
- NCIT_C112004 NCIT_P108 "p70S6K/Akt Inhibitor M-2698" @default.
- NCIT_C112004 NCIT_P208 "CL454293" @default.
- NCIT_C112004 NCIT_P210 "1379545-95-5" @default.
- NCIT_C112004 NCIT_P319 "0DXG50I4WD" @default.
- NCIT_C112004 NCIT_P322 "CTRP" @default.
- NCIT_C112004 NCIT_P322 "FDA" @default.
- NCIT_C112004 NCIT_P322 "GDC" @default.
- NCIT_C112004 NCIT_P329 "754258" @default.
- NCIT_C112004 NCIT_P330 "754258" @default.
- NCIT_C112004 NCIT_P375 "p70S6K/Akt Inhibitor MSC2363318A" @default.
- NCIT_C112004 NCIT_P399 "754258" @default.
- NCIT_C112004 normalizedInformationContent "100" @default.
- NCIT_C112004 referenceCount "1" @default.
- NCIT_C112004 hasExactSynonym "M-2698" @default.
- NCIT_C112004 hasExactSynonym "MSC2363318A" @default.
- NCIT_C112004 hasExactSynonym "p70S6K/Akt Inhibitor M-2698" @default.
- NCIT_C112004 hasExactSynonym "p70S6K/Akt Inhibitor MSC2363318A" @default.
- NCIT_C112004 inSubset NCIT_C116977 @default.
- NCIT_C112004 inSubset NCIT_C116978 @default.
- NCIT_C112004 inSubset NCIT_C128784 @default.
- NCIT_C112004 inSubset NCIT_C157711 @default.
- NCIT_C112004 inSubset NCIT_C157712 @default.
- NCIT_C112004 inSubset NCIT_C176424 @default.
- NCIT_C112004 inSubset NCIT_C177537 @default.
- NCIT_C112004 inSubset NCIT_C63923 @default.
- NCIT_C112004 type Class @default.
- NCIT_C112004 isDefinedBy ncit.owl @default.
- NCIT_C112004 label "p70S6K/Akt Inhibitor M-2698" @default.
- NCIT_C112004 subClassOf NCIT_C112004 @default.
- NCIT_C112004 subClassOf NCIT_C129824 @default.
- NCIT_C112004 subClassOf NCIT_C129825 @default.
- NCIT_C112004 subClassOf NCIT_C1404 @default.
- NCIT_C112004 subClassOf NCIT_C155764 @default.
- NCIT_C112004 subClassOf NCIT_C1742 @default.
- NCIT_C112004 subClassOf NCIT_C1908 @default.
- NCIT_C112004 subClassOf NCIT_C1909 @default.
- NCIT_C112004 subClassOf NCIT_C2189 @default.
- NCIT_C112004 subClassOf NCIT_C274 @default.
- NCIT_C112004 subClassOf NCIT_C471 @default.
- NCIT_C112004 subClassOf NCIT_C61074 @default.