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- NCIT_C112177 IAO_0000115 "A novel histone deacetylase (HDAC) inhibitor with potential antineoplastic activity. Although the exact therapeutic mechanism of action for CXD101 is not known, oral administration of this agent should inhibit the catalytic activity of HDAC, which results in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling and an altered pattern of gene expression. HDAC, a family of enzymes upregulated in many tumor types, deacetylates chromatin-associated histone proteins." @default.
- NCIT_C112177 NCIT_A32 NCIT_C1909 @default.
- NCIT_C112177 NCIT_A7 NCIT_C16682 @default.
- NCIT_C112177 NCIT_NHC0 "C112177" @default.
- NCIT_C112177 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C112177 NCIT_P108 "Zabadinostat" @default.
- NCIT_C112177 NCIT_P208 "CL454389" @default.
- NCIT_C112177 NCIT_P210 "934828-12-3" @default.
- NCIT_C112177 NCIT_P319 "5TNV87ICD2" @default.
- NCIT_C112177 NCIT_P322 "FDA" @default.
- NCIT_C112177 NCIT_P322 "GDC" @default.
- NCIT_C112177 NCIT_P329 "754547" @default.
- NCIT_C112177 NCIT_P330 "754547" @default.
- NCIT_C112177 NCIT_P375 "HDAC Inhibitor CXD101" @default.
- NCIT_C112177 NCIT_P399 "754547" @default.
- NCIT_C112177 normalizedInformationContent "100" @default.
- NCIT_C112177 referenceCount "1" @default.
- NCIT_C112177 hasExactSynonym "AZD 9468" @default.
- NCIT_C112177 hasExactSynonym "AZD9468" @default.
- NCIT_C112177 hasExactSynonym "CXD101" @default.
- NCIT_C112177 hasExactSynonym "HDAC Inhibitor CXD101" @default.
- NCIT_C112177 hasExactSynonym "Histone Deacetylase Inhibitor CXD101" @default.
- NCIT_C112177 hasExactSynonym "ZABADINOSTAT" @default.
- NCIT_C112177 hasExactSynonym "Zabadinostat" @default.
- NCIT_C112177 inSubset NCIT_C128784 @default.
- NCIT_C112177 inSubset NCIT_C157711 @default.
- NCIT_C112177 inSubset NCIT_C157712 @default.
- NCIT_C112177 inSubset NCIT_C176424 @default.
- NCIT_C112177 inSubset NCIT_C177537 @default.
- NCIT_C112177 inSubset NCIT_C63923 @default.
- NCIT_C112177 type Class @default.
- NCIT_C112177 isDefinedBy ncit.owl @default.
- NCIT_C112177 label "Zabadinostat" @default.
- NCIT_C112177 subClassOf NCIT_C112177 @default.
- NCIT_C112177 subClassOf NCIT_C129824 @default.
- NCIT_C112177 subClassOf NCIT_C129825 @default.
- NCIT_C112177 subClassOf NCIT_C163758 @default.
- NCIT_C112177 subClassOf NCIT_C1908 @default.
- NCIT_C112177 subClassOf NCIT_C1909 @default.
- NCIT_C112177 subClassOf NCIT_C1946 @default.
- NCIT_C112177 subClassOf NCIT_C2189 @default.
- NCIT_C112177 subClassOf NCIT_C274 @default.
- NCIT_C112177 subClassOf NCIT_C471 @default.