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- NCIT_C112178 IAO_0000115 "A radiotracer composed of a cyclic Arg-Gly-Asp (RGD) peptide that is conjugated with galactose and radiolabeled with fluorine 18, for potential noninvasive positron emission tomography (PET) imaging of alphaVbeta3 integrin expression. Upon administration, the RGD moiety of the fluorine 18 galacto-RGD peptide selectively binds to alphaVbeta3 integrin. During PET imaging, alphaVbeta3-expressing tumor cells can be visualized and the degree of tumor angiogenesis can be determined. Use of a hydrophilic glycopeptide-based agent may increase retention in the blood and reduce clearance by the liver. This leads to both increased uptake of fluorine 18 galacto-RGD peptide by tumor cells and enhanced PET imaging efficiency, when compared to other agents that are constructed using lipophilic conjugates. AlphaVbeta3 integrin, a cell adhesion and signaling receptor, is upregulated in tumor vessel endothelial cells and has been associated with proliferation of tumor cells, tumor angiogenesis and metastasis." @default.
- NCIT_C112178 NCIT_NHC0 "C112178" @default.
- NCIT_C112178 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C112178 NCIT_P108 "Fluorine F 18 Galacto-RGD Peptide" @default.
- NCIT_C112178 NCIT_P207 "C0965384" @default.
- NCIT_C112178 NCIT_P329 "754549" @default.
- NCIT_C112178 NCIT_P330 "754549" @default.
- NCIT_C112178 NCIT_P399 "754549" @default.
- NCIT_C112178 normalizedInformationContent "100" @default.
- NCIT_C112178 referenceCount "1" @default.
- NCIT_C112178 hasExactSynonym "18F-Galacto-RGD" @default.
- NCIT_C112178 hasExactSynonym "Fluorine F 18 Galacto-RGD Peptide" @default.
- NCIT_C112178 hasExactSynonym "Fluorine F 18 Glycosylated RGD Peptide" @default.
- NCIT_C112178 hasExactSynonym "[18F]Galacto-RGD" @default.
- NCIT_C112178 inSubset NCIT_C176424 @default.
- NCIT_C112178 type Class @default.
- NCIT_C112178 isDefinedBy ncit.owl @default.
- NCIT_C112178 label "Fluorine F 18 Galacto-RGD Peptide" @default.
- NCIT_C112178 subClassOf NCIT_C112178 @default.
- NCIT_C112178 subClassOf NCIT_C1446 @default.
- NCIT_C112178 subClassOf NCIT_C1908 @default.
- NCIT_C112178 subClassOf NCIT_C1909 @default.
- NCIT_C112178 subClassOf NCIT_C2124 @default.