Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C112179> ?p ?o ?g. }
Showing items 1 to 38 of
38
with 100 items per page.
- NCIT_C112179 IAO_0000115 "Allogeneic natural killer (NK) cells transduced with an mRNA expressing a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment) and the zeta chain of the TCR/CD3 complex (CD3-zeta), coupled to the signaling domain of 4-1BB (CD137), with potential immunomodulating and antineoplastic activities. NK cells from haploidentical donors are expanded in culture and electroporated with the CAR mRNA. Upon transfusion of the transduced cultured cells, CD19CAR-CD3zeta-4-1BB-expressing allogeneic NK cells bind to and induce selective cytotoxicity in CD19-expressing tumor cells. The 4-1BB co-stimulatory molecule signaling domain enhances activation and signaling after recognition of CD19. Its inclusion may also increase antitumor activity, when compared to the inclusion of the CD3-zeta chain alone. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies." @default.
- NCIT_C112179 NCIT_NHC0 "C112179" @default.
- NCIT_C112179 NCIT_P106 "Cell" @default.
- NCIT_C112179 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C112179 NCIT_P108 "Anti-CD19-CAR-CD3zeta-4-1BB-Expressing Allogenic Natural Killer Cells" @default.
- NCIT_C112179 NCIT_P208 "CL454390" @default.
- NCIT_C112179 NCIT_P329 "754722" @default.
- NCIT_C112179 NCIT_P330 "754722" @default.
- NCIT_C112179 NCIT_P399 "754722" @default.
- NCIT_C112179 normalizedInformationContent "100" @default.
- NCIT_C112179 referenceCount "1" @default.
- NCIT_C112179 hasExactSynonym "Anti-CD19 Redirected NK Cells" @default.
- NCIT_C112179 hasExactSynonym "Anti-CD19-CAR-CD3zeta-4-1BB-Expressing Allogenic NK Cells" @default.
- NCIT_C112179 hasExactSynonym "Anti-CD19-CAR-CD3zeta-4-1BB-Expressing Allogenic Natural Killer Cells" @default.
- NCIT_C112179 hasExactSynonym "Anti-CD19-CAR-CD3zeta-4-1BB-Expressing Donor NK Cells" @default.
- NCIT_C112179 hasExactSynonym "Anti-CD19-CAR-CD3zeta-4-1BB-Expressing Donor Natural Killer Cells" @default.
- NCIT_C112179 hasExactSynonym "Anti-CD19-CAR-CD3zeta-4-1BB-Expressing NK Cells" @default.
- NCIT_C112179 hasExactSynonym "Anti-CD19-CAR-CD3zeta-4-1BB-Expressing Natural Killer Cells" @default.
- NCIT_C112179 hasExactSynonym "NKCARCD19" @default.
- NCIT_C112179 inSubset NCIT_C128784 @default.
- NCIT_C112179 inSubset NCIT_C176424 @default.
- NCIT_C112179 type Class @default.
- NCIT_C112179 isDefinedBy ncit.owl @default.
- NCIT_C112179 label "Anti-CD19-CAR-CD3zeta-4-1BB-Expressing Allogenic Natural Killer Cells" @default.
- NCIT_C112179 subClassOf NCIT_C112179 @default.
- NCIT_C112179 subClassOf NCIT_C129820 @default.
- NCIT_C112179 subClassOf NCIT_C129821 @default.
- NCIT_C112179 subClassOf NCIT_C129826 @default.
- NCIT_C112179 subClassOf NCIT_C142078 @default.
- NCIT_C112179 subClassOf NCIT_C154231 @default.
- NCIT_C112179 subClassOf NCIT_C1908 @default.
- NCIT_C112179 subClassOf NCIT_C1909 @default.
- NCIT_C112179 subClassOf NCIT_C1962 @default.
- NCIT_C112179 subClassOf NCIT_C201545 @default.
- NCIT_C112179 subClassOf NCIT_C274 @default.
- NCIT_C112179 subClassOf NCIT_C28676 @default.
- NCIT_C112179 subClassOf NCIT_C307 @default.
- NCIT_C112179 subClassOf NCIT_C308 @default.