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- NCIT_C112206 IAO_0000115 "An autologous chronic lymphocytic leukemia cancer vaccine consisting of patient-specific membrane proteins directly extracted from patient autologous tumor cells and incorporated into liposomes along with Interleukin 2 (IL-2) to produce membrane-patched proteoliposomes, with potential immunostimulating and antineoplastic activities. After subcutaneous injection of the autologous tumor cell proteoliposomes chronic lymphocytic leukemia vaccine, liposomes deliver the encapsulated tumor antigens into the cytosol of antigen presenting cells (APCs). Subsequently, the APCs process the antigens and present antigen-derived peptides to the immune system. This may enhance recognition of tumors by the immune system, and activate both cytotoxic CD8+ T cells and CD4+ helper T cells against tumor cells. IL-2 is incorporated into the vaccine to leverage its ability to expand activated T cells." @default.
- NCIT_C112206 NCIT_NHC0 "C112206" @default.
- NCIT_C112206 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C112206 NCIT_P108 "Autologous Tumor Cell Proteoliposome Chronic Lymphocytic Leukemia Vaccine" @default.
- NCIT_C112206 NCIT_P208 "CL454406" @default.
- NCIT_C112206 NCIT_P329 "754522" @default.
- NCIT_C112206 NCIT_P330 "754522" @default.
- NCIT_C112206 NCIT_P399 "754522" @default.
- NCIT_C112206 normalizedInformationContent "100" @default.
- NCIT_C112206 referenceCount "1" @default.
- NCIT_C112206 hasExactSynonym "Autologous Tumor Cell Proteoliposome Chronic Lymphocytic Leukemia Vaccine" @default.
- NCIT_C112206 hasExactSynonym "Oncoquest-CLL Vaccine" @default.
- NCIT_C112206 hasExactSynonym "Oncoquest-L Vaccine" @default.
- NCIT_C112206 inSubset NCIT_C128784 @default.
- NCIT_C112206 inSubset NCIT_C176424 @default.
- NCIT_C112206 type Class @default.
- NCIT_C112206 isDefinedBy ncit.owl @default.
- NCIT_C112206 label "Autologous Tumor Cell Proteoliposome Chronic Lymphocytic Leukemia Vaccine" @default.
- NCIT_C112206 subClassOf NCIT_C112206 @default.
- NCIT_C112206 subClassOf NCIT_C129820 @default.
- NCIT_C112206 subClassOf NCIT_C1663 @default.
- NCIT_C112206 subClassOf NCIT_C1908 @default.
- NCIT_C112206 subClassOf NCIT_C1909 @default.
- NCIT_C112206 subClassOf NCIT_C1980 @default.
- NCIT_C112206 subClassOf NCIT_C2023 @default.
- NCIT_C112206 subClassOf NCIT_C2341 @default.
- NCIT_C112206 subClassOf NCIT_C274 @default.
- NCIT_C112206 subClassOf NCIT_C307 @default.
- NCIT_C112206 subClassOf NCIT_C308 @default.
- NCIT_C112206 subClassOf NCIT_C923 @default.