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- NCIT_C112497 IAO_0000115 "A potent and selective inhibitor of both phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinase in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. PI3K/mTOR kinase inhibitor VS-5584 inhibits mTOR kinase and all class I PI3K isoforms. Consequently, this disrupts phosphorylation of substrates downstream of PI3K and mTOR and may result in apoptosis and growth inhibition in susceptible tumor cells. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy. mTOR is a serine/threonine kinase downstream of PI3K, which also has PI3K-independent activity. Consequently, this agent may potentially be more potent than an agent that inhibits either PI3K kinase or mTOR kinase." @default.
- NCIT_C112497 NCIT_A32 NCIT_C1909 @default.
- NCIT_C112497 NCIT_A7 NCIT_C17270 @default.
- NCIT_C112497 NCIT_NHC0 "C112497" @default.
- NCIT_C112497 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C112497 NCIT_P107 "PI3K/mTOR Kinase Inhibitor VS-5584" @default.
- NCIT_C112497 NCIT_P108 "PI3K/mTOR Kinase Inhibitor VS-5584" @default.
- NCIT_C112497 NCIT_P207 "C3711165" @default.
- NCIT_C112497 NCIT_P210 "1246560-33-7" @default.
- NCIT_C112497 NCIT_P319 "W71J4X250V" @default.
- NCIT_C112497 NCIT_P322 "CTRP" @default.
- NCIT_C112497 NCIT_P322 "FDA" @default.
- NCIT_C112497 NCIT_P322 "GDC" @default.
- NCIT_C112497 NCIT_P329 "755179" @default.
- NCIT_C112497 NCIT_P330 "755179" @default.
- NCIT_C112497 NCIT_P375 "PI3K/mTOR Kinase Inhibitor VS-5584" @default.
- NCIT_C112497 NCIT_P399 "755179" @default.
- NCIT_C112497 normalizedInformationContent "100" @default.
- NCIT_C112497 referenceCount "1" @default.
- NCIT_C112497 hasExactSynonym "2-Pyrimidinamine, 5-[8-Methyl-9-(1-Methylethyl)-2-(4-Morpholinyl)-9H-Purin-6-Yl]-2-" @default.
- NCIT_C112497 hasExactSynonym "5-[8-Methyl-9-(1-Methylethyl)-2-(4-Morpholinyl)-9H-Purin-6-Yl]-2-Pyrimidinamine" @default.
- NCIT_C112497 hasExactSynonym "PI3K/mTOR Inhibitor VS-5584" @default.
- NCIT_C112497 hasExactSynonym "PI3K/mTOR Kinase Inhibitor VS-5584" @default.
- NCIT_C112497 hasExactSynonym "SB 2343" @default.
- NCIT_C112497 hasExactSynonym "SB-2343" @default.
- NCIT_C112497 hasExactSynonym "SB2343" @default.
- NCIT_C112497 hasExactSynonym "VS 5584" @default.
- NCIT_C112497 hasExactSynonym "VS-5584" @default.
- NCIT_C112497 hasExactSynonym "VS5584" @default.
- NCIT_C112497 inSubset NCIT_C116977 @default.
- NCIT_C112497 inSubset NCIT_C116978 @default.
- NCIT_C112497 inSubset NCIT_C128784 @default.
- NCIT_C112497 inSubset NCIT_C157711 @default.
- NCIT_C112497 inSubset NCIT_C157712 @default.
- NCIT_C112497 inSubset NCIT_C176424 @default.
- NCIT_C112497 inSubset NCIT_C177537 @default.
- NCIT_C112497 inSubset NCIT_C63923 @default.
- NCIT_C112497 type Class @default.
- NCIT_C112497 isDefinedBy ncit.owl @default.
- NCIT_C112497 label "PI3K/mTOR Kinase Inhibitor VS-5584" @default.
- NCIT_C112497 subClassOf NCIT_C112497 @default.
- NCIT_C112497 subClassOf NCIT_C129824 @default.
- NCIT_C112497 subClassOf NCIT_C129825 @default.
- NCIT_C112497 subClassOf NCIT_C1404 @default.
- NCIT_C112497 subClassOf NCIT_C163758 @default.
- NCIT_C112497 subClassOf NCIT_C1742 @default.
- NCIT_C112497 subClassOf NCIT_C1908 @default.
- NCIT_C112497 subClassOf NCIT_C1909 @default.
- NCIT_C112497 subClassOf NCIT_C2152 @default.
- NCIT_C112497 subClassOf NCIT_C2189 @default.
- NCIT_C112497 subClassOf NCIT_C274 @default.
- NCIT_C112497 subClassOf NCIT_C471 @default.