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- NCIT_C112498 IAO_0000115 "An extended release (ER) oral tablet that contains flucytosine (5-FC), a fluorinated cytosine analog, with antifungal activity and potential anti-cancer activity. Following oral administration of ER 5-FC, the 5-FC is deaminated to its active metabolite 5-fluorouracil (5-FU). 5-FU replaces uracil during RNA synthesis, which consequently inhibits downstream protein synthesis. In addition, 5-FU is metabolized further to 5-fluorodeoxyuridylic acid monophosphate, which inhibits thymidylate synthetase. Inhibition of this enzyme interrupts nucleotide synthesis, DNA replication and cell proliferation. Negative regulation of protein synthesis, DNA replication and cell proliferation can lead to cell death. Following ingestion of ER 5-FC, intravenous injection of a retroviral vector encoding cytosine deaminase (TC 511) at a tumor site may result in higher local concentrations of 5-FU and its metabolites, and increased tumor cell death than other 5-FU treatment regimens." @default.
- NCIT_C112498 NCIT_A32 NCIT_C1909 @default.
- NCIT_C112498 NCIT_NHC0 "C112498" @default.
- NCIT_C112498 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C112498 NCIT_P107 "Extended Release Flucytosine" @default.
- NCIT_C112498 NCIT_P108 "Extended Release Flucytosine" @default.
- NCIT_C112498 NCIT_P208 "CL454672" @default.
- NCIT_C112498 NCIT_P322 "CTRP" @default.
- NCIT_C112498 NCIT_P322 "GDC" @default.
- NCIT_C112498 NCIT_P329 "755027" @default.
- NCIT_C112498 NCIT_P330 "755027" @default.
- NCIT_C112498 NCIT_P375 "Extended Release Flucytosine" @default.
- NCIT_C112498 NCIT_P399 "755027" @default.
- NCIT_C112498 normalizedInformationContent "100" @default.
- NCIT_C112498 referenceCount "1" @default.
- NCIT_C112498 hasExactSynonym "Extended Release 5-FC" @default.
- NCIT_C112498 hasExactSynonym "Extended Release 5-Fluorocytosine" @default.
- NCIT_C112498 hasExactSynonym "Extended Release Flucytosine" @default.
- NCIT_C112498 hasExactSynonym "Extended-Release 5-FC" @default.
- NCIT_C112498 hasExactSynonym "Extended-Release 5-Fluorocytosine" @default.
- NCIT_C112498 hasExactSynonym "Extended-Release Flucytosine" @default.
- NCIT_C112498 hasExactSynonym "Toca FC" @default.
- NCIT_C112498 inSubset NCIT_C116977 @default.
- NCIT_C112498 inSubset NCIT_C116978 @default.
- NCIT_C112498 inSubset NCIT_C128784 @default.
- NCIT_C112498 inSubset NCIT_C157711 @default.
- NCIT_C112498 inSubset NCIT_C157712 @default.
- NCIT_C112498 inSubset NCIT_C176424 @default.
- NCIT_C112498 inSubset NCIT_C177537 @default.
- NCIT_C112498 type Class @default.
- NCIT_C112498 isDefinedBy ncit.owl @default.
- NCIT_C112498 label "Extended Release Flucytosine" @default.
- NCIT_C112498 subClassOf NCIT_C112498 @default.
- NCIT_C112498 subClassOf NCIT_C1557 @default.
- NCIT_C112498 subClassOf NCIT_C186664 @default.
- NCIT_C112498 subClassOf NCIT_C1908 @default.
- NCIT_C112498 subClassOf NCIT_C1909 @default.
- NCIT_C112498 subClassOf NCIT_C272 @default.
- NCIT_C112498 subClassOf NCIT_C274 @default.