Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C112500> ?p ?o ?g. }
Showing items 1 to 48 of
48
with 100 items per page.
- NCIT_C112500 IAO_0000115 "A small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins with potential antineoplastic activity. Upon administration, the BET inhibitor RO6870810 binds to the acetylated lysine recognition motifs found in the bromodomain of BET proteins, which prevents the interaction between BET proteins and acetylated histones. This interaction disrupts chromatin remodeling and gene expression. Prevention of the expression of certain growth-promoting genes may lead to an inhibition of tumor cell growth. Characterized by a tandem repeat of bromodomains at the N-terminus, BET proteins, comprised of BRD2, BRD3, BRD4 and BRDT, are transcriptional regulators that play an important role during cellular development and growth." @default.
- NCIT_C112500 NCIT_A32 NCIT_C1909 @default.
- NCIT_C112500 NCIT_A7 NCIT_C106463 @default.
- NCIT_C112500 NCIT_A7 NCIT_C21376 @default.
- NCIT_C112500 NCIT_A7 NCIT_C92704 @default.
- NCIT_C112500 NCIT_A7 NCIT_C97399 @default.
- NCIT_C112500 NCIT_NHC0 "C112500" @default.
- NCIT_C112500 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C112500 NCIT_P107 "BET Inhibitor RO6870810" @default.
- NCIT_C112500 NCIT_P108 "BET Inhibitor RO6870810" @default.
- NCIT_C112500 NCIT_P208 "CL454674" @default.
- NCIT_C112500 NCIT_P210 "1349719-98-7" @default.
- NCIT_C112500 NCIT_P319 "TA3QN7788D" @default.
- NCIT_C112500 NCIT_P322 "CTRP" @default.
- NCIT_C112500 NCIT_P322 "FDA" @default.
- NCIT_C112500 NCIT_P322 "GDC" @default.
- NCIT_C112500 NCIT_P329 "755021" @default.
- NCIT_C112500 NCIT_P330 "755021" @default.
- NCIT_C112500 NCIT_P375 "BET Inhibitor RO6870810" @default.
- NCIT_C112500 NCIT_P399 "755021" @default.
- NCIT_C112500 normalizedInformationContent "100" @default.
- NCIT_C112500 referenceCount "1" @default.
- NCIT_C112500 hasExactSynonym "BET Inhibitor RO6870810" @default.
- NCIT_C112500 hasExactSynonym "Bromodomain and Extra-Terminal Protein Inhibitor RO6870810" @default.
- NCIT_C112500 hasExactSynonym "RG 6146" @default.
- NCIT_C112500 hasExactSynonym "RG6146" @default.
- NCIT_C112500 hasExactSynonym "RO-6870810" @default.
- NCIT_C112500 hasExactSynonym "RO6870810" @default.
- NCIT_C112500 hasExactSynonym "TEN 010" @default.
- NCIT_C112500 hasExactSynonym "TEN-010" @default.
- NCIT_C112500 inSubset NCIT_C116977 @default.
- NCIT_C112500 inSubset NCIT_C116978 @default.
- NCIT_C112500 inSubset NCIT_C128784 @default.
- NCIT_C112500 inSubset NCIT_C157711 @default.
- NCIT_C112500 inSubset NCIT_C157712 @default.
- NCIT_C112500 inSubset NCIT_C176424 @default.
- NCIT_C112500 inSubset NCIT_C177537 @default.
- NCIT_C112500 inSubset NCIT_C63923 @default.
- NCIT_C112500 type Class @default.
- NCIT_C112500 isDefinedBy ncit.owl @default.
- NCIT_C112500 label "BET Inhibitor RO6870810" @default.
- NCIT_C112500 subClassOf NCIT_C112500 @default.
- NCIT_C112500 subClassOf NCIT_C128462 @default.
- NCIT_C112500 subClassOf NCIT_C129824 @default.
- NCIT_C112500 subClassOf NCIT_C1908 @default.
- NCIT_C112500 subClassOf NCIT_C1909 @default.
- NCIT_C112500 subClassOf NCIT_C2189 @default.
- NCIT_C112500 subClassOf NCIT_C274 @default.