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- NCIT_C113162 IAO_0000115 "An inhibitor of spleen tyrosine kinase (syk), with potential anti-inflammatory, immunomodulating, and antineoplastic activities. Upon administration, mivavotinib may inhibit the activity of syk, which abrogates downstream B-cell receptor (BCR) signaling and leads to an inhibition of B-cell activation, chemotaxis, adhesion and proliferation. Syk, a BCR-associated non-receptor tyrosine kinase that mediates diverse cellular responses, including proliferation, differentiation, and phagocytosis, is expressed in hematopoietic tissues and is often overexpressed in hematopoietic malignancies." @default.
- NCIT_C113162 NCIT_A32 NCIT_C1909 @default.
- NCIT_C113162 NCIT_A7 NCIT_C18169 @default.
- NCIT_C113162 NCIT_NHC0 "C113162" @default.
- NCIT_C113162 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C113162 NCIT_P107 "Mivavotinib" @default.
- NCIT_C113162 NCIT_P108 "Mivavotinib" @default.
- NCIT_C113162 NCIT_P208 "CL455236" @default.
- NCIT_C113162 NCIT_P210 "1312691-33-0" @default.
- NCIT_C113162 NCIT_P319 "8QR88H79VX" @default.
- NCIT_C113162 NCIT_P322 "CTRP" @default.
- NCIT_C113162 NCIT_P322 "FDA" @default.
- NCIT_C113162 NCIT_P322 "GDC" @default.
- NCIT_C113162 NCIT_P329 "755930" @default.
- NCIT_C113162 NCIT_P330 "755930" @default.
- NCIT_C113162 NCIT_P375 "Mivavotinib" @default.
- NCIT_C113162 NCIT_P399 "755930" @default.
- NCIT_C113162 normalizedInformationContent "100" @default.
- NCIT_C113162 referenceCount "1" @default.
- NCIT_C113162 hasExactSynonym "3H-Pyrrolo(3,4-C)pyridin-3-one, 6-(((1R,2S)-2-aminocyclohexyl)amino)-7-fluoro-1,2-dihydro-4-(1-methyl-1H-pyrazol-4-yl)-" @default.
- NCIT_C113162 hasExactSynonym "MIVAVOTINIB" @default.
- NCIT_C113162 hasExactSynonym "Mivavotinib" @default.
- NCIT_C113162 hasExactSynonym "Spleen Tyrosine Kinase Inhibitor TAK659" @default.
- NCIT_C113162 hasExactSynonym "TAK-659 Free Base" @default.
- NCIT_C113162 hasExactSynonym "TAK659 Free Base" @default.
- NCIT_C113162 hasExactSynonym "syk Inhibitor TAK-659" @default.
- NCIT_C113162 hasExactSynonym "syk Inhibitor TAK659" @default.
- NCIT_C113162 hasExactSynonym "syk-Inhibitor TAK-659" @default.
- NCIT_C113162 hasExactSynonym "syk-Inhibitor TAK659" @default.
- NCIT_C113162 inSubset NCIT_C116977 @default.
- NCIT_C113162 inSubset NCIT_C116978 @default.
- NCIT_C113162 inSubset NCIT_C128784 @default.
- NCIT_C113162 inSubset NCIT_C157711 @default.
- NCIT_C113162 inSubset NCIT_C157712 @default.
- NCIT_C113162 inSubset NCIT_C176424 @default.
- NCIT_C113162 inSubset NCIT_C177537 @default.
- NCIT_C113162 inSubset NCIT_C63923 @default.
- NCIT_C113162 type Class @default.
- NCIT_C113162 isDefinedBy ncit.owl @default.
- NCIT_C113162 label "Mivavotinib" @default.
- NCIT_C113162 subClassOf NCIT_C113162 @default.
- NCIT_C113162 subClassOf NCIT_C129824 @default.
- NCIT_C113162 subClassOf NCIT_C129825 @default.
- NCIT_C113162 subClassOf NCIT_C1404 @default.
- NCIT_C113162 subClassOf NCIT_C1908 @default.
- NCIT_C113162 subClassOf NCIT_C1909 @default.
- NCIT_C113162 subClassOf NCIT_C1967 @default.
- NCIT_C113162 subClassOf NCIT_C2189 @default.
- NCIT_C113162 subClassOf NCIT_C274 @default.
- NCIT_C113162 subClassOf NCIT_C471 @default.