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- NCIT_C113163 IAO_0000115 "A recombinant sialidase fusion protein composed of a sialidase catalytic domain derived from Actinomyces viscosus, a constituent of the normal oral and gastrointestinal flora in humans, fused to a cell surface-anchoring domain, with potential anti-viral activity. Following administration by oral inhalation, oplunofusp proteolytically removes sialic acid from the airway epithelium, which inhibits viral binding to and internalization by cells of the respiratory epithelium and prevents viral replication. The cell surface anchoring-domain of this agent may increase retention time and drug potency. Sialic acids in the respiratory tract are used by influenza and parainfluenza viruses to invade airway epithelial cells." @default.
- NCIT_C113163 NCIT_NHC0 "C113163" @default.
- NCIT_C113163 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C113163 NCIT_P107 "Oplunofusp" @default.
- NCIT_C113163 NCIT_P108 "Oplunofusp" @default.
- NCIT_C113163 NCIT_P207 "C2003387" @default.
- NCIT_C113163 NCIT_P210 "946032-08-2" @default.
- NCIT_C113163 NCIT_P319 "227R1C272Q" @default.
- NCIT_C113163 NCIT_P322 "CTRP" @default.
- NCIT_C113163 NCIT_P322 "FDA" @default.
- NCIT_C113163 NCIT_P329 "755932" @default.
- NCIT_C113163 NCIT_P330 "755932" @default.
- NCIT_C113163 NCIT_P399 "755932" @default.
- NCIT_C113163 normalizedInformationContent "100" @default.
- NCIT_C113163 referenceCount "1" @default.
- NCIT_C113163 hasExactSynonym "273-666-Neuraminidase [273-Methionine] (Actinomyces viscosus Clone DAS181) Fusion Protein With 125-145-Preproamphiregulin (Human)" @default.
- NCIT_C113163 hasExactSynonym "DAS181" @default.
- NCIT_C113163 hasExactSynonym "DAS181-F02" @default.
- NCIT_C113163 hasExactSynonym "Fludase" @default.
- NCIT_C113163 hasExactSynonym "OPLUNOFUSP" @default.
- NCIT_C113163 hasExactSynonym "Oplunofusp" @default.
- NCIT_C113163 hasExactSynonym "Recombinant Cell-Surface Anchored Sialidase DAS181" @default.
- NCIT_C113163 inSubset NCIT_C116977 @default.
- NCIT_C113163 inSubset NCIT_C116978 @default.
- NCIT_C113163 inSubset NCIT_C173381 @default.
- NCIT_C113163 inSubset NCIT_C173383 @default.
- NCIT_C113163 inSubset NCIT_C176424 @default.
- NCIT_C113163 inSubset NCIT_C63923 @default.
- NCIT_C113163 type Class @default.
- NCIT_C113163 isDefinedBy ncit.owl @default.
- NCIT_C113163 label "Oplunofusp" @default.
- NCIT_C113163 subClassOf NCIT_C113163 @default.
- NCIT_C113163 subClassOf NCIT_C1908 @default.
- NCIT_C113163 subClassOf NCIT_C1909 @default.
- NCIT_C113163 subClassOf NCIT_C78273 @default.