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- NCIT_C113173 IAO_0000115 "An orally bioavailable dual inhibitor of spleen tyrosine kinase (Syk) and Janus-associated kinases (JAK), with potential anti-inflammatory and antineoplastic activity. Upon oral administration, cerdulatinib specifically binds to and inhibits the activity of Syk, JAK1, and JAK3 with preferential inhibition of JAK1 and JAK3-dependent cytokine-mediated signaling and functional responses. This negatively affects the downstream JAK-STAT (signal transducer and activator of transcription) pathway, and leads to both reduced inflammation in various animal models and enhanced antiproliferative activity towards non-Hodgkin's lymphoma (NHL) cell lines. Syk is a non-receptor cytoplasmic tyrosine kinase involved in signal transduction in cells of hematopoietic origin including B cells, macrophages, basophils and neutrophils. Abnormal function of Syk has been implicated in several hematopoietic malignancies including NHL and chronic lymphocytic leukemia (CLL). The JAK-STAT pathway plays a key role in the signaling of many cytokines and growth factors and is involved in cellular proliferation, growth, hematopoiesis, and the immune response; JAK kinases may be upregulated in inflammatory diseases, myeloproliferative disorders, and various malignancies." @default.
- NCIT_C113173 NCIT_A32 NCIT_C1909 @default.
- NCIT_C113173 NCIT_A7 NCIT_C18169 @default.
- NCIT_C113173 NCIT_A7 NCIT_C28492 @default.
- NCIT_C113173 NCIT_A7 NCIT_C28493 @default.
- NCIT_C113173 NCIT_A7 NCIT_C28494 @default.
- NCIT_C113173 NCIT_NHC0 "C113173" @default.
- NCIT_C113173 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C113173 NCIT_P107 "Cerdulatinib" @default.
- NCIT_C113173 NCIT_P108 "Cerdulatinib" @default.
- NCIT_C113173 NCIT_P207 "C3827083" @default.
- NCIT_C113173 NCIT_P210 "1198300-79-6" @default.
- NCIT_C113173 NCIT_P319 "D1LXQ45S1O" @default.
- NCIT_C113173 NCIT_P322 "CTRP" @default.
- NCIT_C113173 NCIT_P322 "FDA" @default.
- NCIT_C113173 NCIT_P322 "GDC" @default.
- NCIT_C113173 NCIT_P329 "755483" @default.
- NCIT_C113173 NCIT_P330 "755483" @default.
- NCIT_C113173 NCIT_P375 "Cerdulatinib" @default.
- NCIT_C113173 NCIT_P399 "755483" @default.
- NCIT_C113173 normalizedInformationContent "100" @default.
- NCIT_C113173 referenceCount "1" @default.
- NCIT_C113173 hasExactSynonym "CERDULATINIB" @default.
- NCIT_C113173 hasExactSynonym "Cerdulatinib" @default.
- NCIT_C113173 hasExactSynonym "PRT-062070" @default.
- NCIT_C113173 hasExactSynonym "PRT062070" @default.
- NCIT_C113173 hasExactSynonym "Syk-JAK Inhibitor PRT062070" @default.
- NCIT_C113173 hasExactSynonym "Syk/JAK Inhibitor PRT062070" @default.
- NCIT_C113173 inSubset NCIT_C116977 @default.
- NCIT_C113173 inSubset NCIT_C116978 @default.
- NCIT_C113173 inSubset NCIT_C128784 @default.
- NCIT_C113173 inSubset NCIT_C157711 @default.
- NCIT_C113173 inSubset NCIT_C157712 @default.
- NCIT_C113173 inSubset NCIT_C176424 @default.
- NCIT_C113173 inSubset NCIT_C177537 @default.
- NCIT_C113173 inSubset NCIT_C63923 @default.
- NCIT_C113173 type Class @default.
- NCIT_C113173 isDefinedBy ncit.owl @default.
- NCIT_C113173 label "Cerdulatinib" @default.
- NCIT_C113173 subClassOf NCIT_C113173 @default.
- NCIT_C113173 subClassOf NCIT_C129824 @default.
- NCIT_C113173 subClassOf NCIT_C129825 @default.
- NCIT_C113173 subClassOf NCIT_C1404 @default.
- NCIT_C113173 subClassOf NCIT_C1908 @default.
- NCIT_C113173 subClassOf NCIT_C1909 @default.
- NCIT_C113173 subClassOf NCIT_C1967 @default.
- NCIT_C113173 subClassOf NCIT_C2189 @default.
- NCIT_C113173 subClassOf NCIT_C274 @default.
- NCIT_C113173 subClassOf NCIT_C471 @default.