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- NCIT_C113175 IAO_0000115 "Polymeric micellar nanoparticles containing diaminocyclohexane platinum (DACH-platin or DACH-Pt) with potential antineoplastic activity. DACH-platin micelle NC-4016 is prepared through the formation of a polymer-metal complex between DACH-platin and the polyethylene glycol-poly (glutamic acid) block copolymer, PEG-P(Glu). DACH-platin, an active metabolite of the platinum-based antineoplastic agent oxaliplatin, is highly hydrophobic and toxic when administered systemically. The use of polymeric micelles incorporating DACH-platin may both increase cell permeability and enhance the retention of the agent. This allows an extended half-life in the blood circulation and a selective and high accumulation of DACH-platin at tumor sites. This results in increased anticancer efficacy while reducing side effects due to DACH-platin toxicity. Upon intravenous administration and internalization by tumor cells, DACH-platin binds to and causes both inter- and intra-strand cross-links in DNA, forming platinum adducts and triggering tumor cell apoptosis." @default.
- NCIT_C113175 NCIT_A32 NCIT_C1909 @default.
- NCIT_C113175 NCIT_NHC0 "C113175" @default.
- NCIT_C113175 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C113175 NCIT_P108 "DACH-Platin Micelle NC-4016" @default.
- NCIT_C113175 NCIT_P208 "CL455246" @default.
- NCIT_C113175 NCIT_P322 "GDC" @default.
- NCIT_C113175 NCIT_P329 "755556" @default.
- NCIT_C113175 NCIT_P330 "755556" @default.
- NCIT_C113175 NCIT_P375 "DACH-Platin Micelle NC-4016" @default.
- NCIT_C113175 NCIT_P399 "755556" @default.
- NCIT_C113175 normalizedInformationContent "100" @default.
- NCIT_C113175 referenceCount "1" @default.
- NCIT_C113175 hasExactSynonym "DACH-Platin Micelle NC-4016" @default.
- NCIT_C113175 hasExactSynonym "DACH-Pt/m NC-4016" @default.
- NCIT_C113175 hasExactSynonym "Dach-Platin Micelle NC-4016" @default.
- NCIT_C113175 hasExactSynonym "Diaminocyclohexane Platinum Micelle NC-4016" @default.
- NCIT_C113175 hasExactSynonym "NC-4016" @default.
- NCIT_C113175 inSubset NCIT_C128784 @default.
- NCIT_C113175 inSubset NCIT_C157711 @default.
- NCIT_C113175 inSubset NCIT_C157712 @default.
- NCIT_C113175 inSubset NCIT_C176424 @default.
- NCIT_C113175 inSubset NCIT_C177537 @default.
- NCIT_C113175 type Class @default.
- NCIT_C113175 isDefinedBy ncit.owl @default.
- NCIT_C113175 label "DACH-Platin Micelle NC-4016" @default.
- NCIT_C113175 subClassOf NCIT_C113175 @default.
- NCIT_C113175 subClassOf NCIT_C1450 @default.
- NCIT_C113175 subClassOf NCIT_C1590 @default.
- NCIT_C113175 subClassOf NCIT_C186664 @default.
- NCIT_C113175 subClassOf NCIT_C1908 @default.
- NCIT_C113175 subClassOf NCIT_C1909 @default.
- NCIT_C113175 subClassOf NCIT_C2163 @default.
- NCIT_C113175 subClassOf NCIT_C274 @default.
- NCIT_C113175 subClassOf NCIT_C2842 @default.
- NCIT_C113175 subClassOf NCIT_C798 @default.