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- NCIT_C113236 IAO_0000115 "An intermediate product of the kynurenine pathway, which is responsible for the conversion of the amino acid tryptophan into nicotinamide adenine dinucleotide, with potential neurotoxic activity. If produced in excess, quinolinic acid can cross the blood-brain barrier (BBB) and function as an N-methyl-D-aspartate (NMDA) receptor agonist, which may lead to both neuronal damage and neurodegenerative brain disease. The NMDA receptor, a heterotetrameric, ligand-gated and voltage-dependent glutamate receptor, is critical for synaptic plasticity, learning and memory." @default.
- NCIT_C113236 NCIT_NHC0 "C113236" @default.
- NCIT_C113236 NCIT_P106 "Organic Chemical" @default.
- NCIT_C113236 NCIT_P107 "Quinolinic Acid" @default.
- NCIT_C113236 NCIT_P108 "Quinolinic Acid" @default.
- NCIT_C113236 NCIT_P207 "C0072879" @default.
- NCIT_C113236 NCIT_P210 "89-00-9" @default.
- NCIT_C113236 NCIT_P319 "F6F0HK1URN" @default.
- NCIT_C113236 NCIT_P322 "CTRP" @default.
- NCIT_C113236 NCIT_P322 "FDA" @default.
- NCIT_C113236 NCIT_P368 "CHEBI:16675" @default.
- NCIT_C113236 normalizedInformationContent "100" @default.
- NCIT_C113236 referenceCount "1" @default.
- NCIT_C113236 hasExactSynonym "2,3-Pyridinedicarboxylic Acid" @default.
- NCIT_C113236 hasExactSynonym "Pyridine-2,3-Dicarboxylic Acid" @default.
- NCIT_C113236 hasExactSynonym "QA" @default.
- NCIT_C113236 hasExactSynonym "QUIN" @default.
- NCIT_C113236 hasExactSynonym "QUINOLINIC ACID" @default.
- NCIT_C113236 hasExactSynonym "Quinolinic Acid" @default.
- NCIT_C113236 inSubset NCIT_C116977 @default.
- NCIT_C113236 inSubset NCIT_C142799 @default.
- NCIT_C113236 inSubset NCIT_C63923 @default.
- NCIT_C113236 type Class @default.
- NCIT_C113236 isDefinedBy ncit.owl @default.
- NCIT_C113236 label "Quinolinic Acid" @default.
- NCIT_C113236 subClassOf NCIT_C113236 @default.
- NCIT_C113236 subClassOf NCIT_C1908 @default.
- NCIT_C113236 subClassOf NCIT_C1913 @default.
- NCIT_C113236 subClassOf NCIT_C1933 @default.
- NCIT_C113236 subClassOf NCIT_C542 @default.
- NCIT_C113236 subClassOf NCIT_C718 @default.