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- NCIT_C113293 IAO_0000115 "An orally bioavailable small molecule inhibitor of phosphorylated-p68 RNA helicase (P-p68), with potential anti-proliferative and antineoplastic activity. Upon oral administration, P-p68 inhibitor RX-5902 may both inhibit the activity of the anti-apoptotic B-cell lymphoma 2 (Bcl-2) protein and facilitate the induction of cyclin-dependent kinase inhibitor 1 (p21). This may prevent G2/M cell cycle progression and lead to growth inhibition in tumor cells. P-p68 is overexpressed in various types of solid tumors but absent in normal tissues, and plays a role in tumor progression and metastasis. p21 is a potent cyclin-dependent kinase inhibitor which regulates cell cycle progression and mediates both growth arrest and cellular senescence." @default.
- NCIT_C113293 NCIT_A32 NCIT_C1909 @default.
- NCIT_C113293 NCIT_NHC0 "C113293" @default.
- NCIT_C113293 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C113293 NCIT_P107 "P-p68 Inhibitor RX-5902" @default.
- NCIT_C113293 NCIT_P108 "P-p68 Inhibitor RX-5902" @default.
- NCIT_C113293 NCIT_P207 "C3827081" @default.
- NCIT_C113293 NCIT_P210 "888478-45-3" @default.
- NCIT_C113293 NCIT_P319 "ZU8OM8V5WF" @default.
- NCIT_C113293 NCIT_P322 "CTRP" @default.
- NCIT_C113293 NCIT_P322 "FDA" @default.
- NCIT_C113293 NCIT_P322 "GDC" @default.
- NCIT_C113293 NCIT_P329 "755944" @default.
- NCIT_C113293 NCIT_P330 "755944" @default.
- NCIT_C113293 NCIT_P375 "P-p68 Inhibitor RX-5902" @default.
- NCIT_C113293 NCIT_P399 "755944" @default.
- NCIT_C113293 normalizedInformationContent "100" @default.
- NCIT_C113293 referenceCount "1" @default.
- NCIT_C113293 hasExactSynonym "P-p68 Inhibitor RX-5902" @default.
- NCIT_C113293 hasExactSynonym "RX-5902" @default.
- NCIT_C113293 hasExactSynonym "SUPINOXIN" @default.
- NCIT_C113293 hasExactSynonym "Supinoxin" @default.
- NCIT_C113293 inSubset NCIT_C116977 @default.
- NCIT_C113293 inSubset NCIT_C116978 @default.
- NCIT_C113293 inSubset NCIT_C128784 @default.
- NCIT_C113293 inSubset NCIT_C157711 @default.
- NCIT_C113293 inSubset NCIT_C157712 @default.
- NCIT_C113293 inSubset NCIT_C176424 @default.
- NCIT_C113293 inSubset NCIT_C177537 @default.
- NCIT_C113293 inSubset NCIT_C63923 @default.
- NCIT_C113293 type Class @default.
- NCIT_C113293 isDefinedBy ncit.owl @default.
- NCIT_C113293 label "P-p68 Inhibitor RX-5902" @default.
- NCIT_C113293 subClassOf NCIT_C113293 @default.
- NCIT_C113293 subClassOf NCIT_C1908 @default.
- NCIT_C113293 subClassOf NCIT_C1909 @default.
- NCIT_C113293 subClassOf NCIT_C471 @default.