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- NCIT_C113295 IAO_0000115 "A covalent conjugate of recombinant human interleukin-10 (IL-10) and polyethylene glycol (PEG), with potential anti-fibrotic, anti-inflammatory, immunomodulating and antineoplastic activities. Upon subcutaneous administration, pegilodecakin may activate cell-mediated immunity against cancer cells by stimulating the differentiation and expansion of tumor specific cytotoxic CD8+ T cells. This agent may also lower serum cholesterol levels and reduce atherosclerotic plaques by inhibiting the synthesis of pro-inflammatory cytokines, such as Interferon-gamma, IL-2, IL-3, TNF-alpha, and GM-CSF. The PEG moiety inhibits proteolytic breakdown and clearance of AM0010, which prolongs its half-life, extends the duration of its therapeutic effects and allows less frequent dosing." @default.
- NCIT_C113295 NCIT_A32 NCIT_C1909 @default.
- NCIT_C113295 NCIT_NHC0 "C113295" @default.
- NCIT_C113295 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C113295 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C113295 NCIT_P108 "Pegilodecakin" @default.
- NCIT_C113295 NCIT_P208 "CL458142" @default.
- NCIT_C113295 NCIT_P210 "1966111-35-2" @default.
- NCIT_C113295 NCIT_P319 "5Z9850I25F" @default.
- NCIT_C113295 NCIT_P322 "FDA" @default.
- NCIT_C113295 NCIT_P322 "GDC" @default.
- NCIT_C113295 NCIT_P329 "756011" @default.
- NCIT_C113295 NCIT_P330 "756011" @default.
- NCIT_C113295 NCIT_P375 "Pegilodecakin" @default.
- NCIT_C113295 NCIT_P399 "756011" @default.
- NCIT_C113295 NCIT_R125 NCIT_C17828 @default.
- NCIT_C113295 NCIT_R125 NCIT_C17937 @default.
- NCIT_C113295 NCIT_R125 NCIT_C18081 @default.
- NCIT_C113295 NCIT_R125 NCIT_C18095 @default.
- NCIT_C113295 NCIT_R125 NCIT_C18839 @default.
- NCIT_C113295 NCIT_R125 NCIT_C20480 @default.
- NCIT_C113295 NCIT_R125 NCIT_C20751 @default.
- NCIT_C113295 NCIT_R125 NCIT_C21124 @default.
- NCIT_C113295 NCIT_R125 NCIT_C40912 @default.
- NCIT_C113295 normalizedInformationContent "100" @default.
- NCIT_C113295 referenceCount "1" @default.
- NCIT_C113295 hasExactSynonym "AM-0010" @default.
- NCIT_C113295 hasExactSynonym "AM0010" @default.
- NCIT_C113295 hasExactSynonym "PEG-rHuIL-10 AM0010" @default.
- NCIT_C113295 hasExactSynonym "PEGILODECAKIN" @default.
- NCIT_C113295 hasExactSynonym "Pegilodecakin" @default.
- NCIT_C113295 inSubset NCIT_C128784 @default.
- NCIT_C113295 inSubset NCIT_C157711 @default.
- NCIT_C113295 inSubset NCIT_C157712 @default.
- NCIT_C113295 inSubset NCIT_C176424 @default.
- NCIT_C113295 inSubset NCIT_C177537 @default.
- NCIT_C113295 inSubset NCIT_C63923 @default.
- NCIT_C113295 type Class @default.
- NCIT_C113295 isDefinedBy ncit.owl @default.
- NCIT_C113295 label "Pegilodecakin" @default.
- NCIT_C113295 subClassOf NCIT_C113295 @default.
- NCIT_C113295 subClassOf NCIT_C1283 @default.
- NCIT_C113295 subClassOf NCIT_C1320 @default.
- NCIT_C113295 subClassOf NCIT_C1908 @default.
- NCIT_C113295 subClassOf NCIT_C1909 @default.
- NCIT_C113295 subClassOf NCIT_C307 @default.
- NCIT_C113295 subClassOf NCIT_C308 @default.
- NCIT_C113295 subClassOf NCIT_C593 @default.