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- NCIT_C113333 IAO_0000115 "A human monoclonal antibody directed against the human epidermal growth factor receptor ErbB3 (HER3), with potential antineoplastic activity. Upon administration, the anti-ErbB3 monoclonal antibody CDX-3379 targets and binds to a unique epitope on ErbB3, thereby preventing ErbB3 phosphorylation and both ligand-dependent and ligand-independent ErbB3 signaling. This inhibits cellular proliferation and survival of ErbB3-expressing tumor cells. ErbB3, a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, is frequently overexpressed in a variety of tumors and its overexpression generally correlates with poor prognosis and tumor resistance." @default.
- NCIT_C113333 NCIT_A32 NCIT_C1909 @default.
- NCIT_C113333 NCIT_A7 NCIT_C18490 @default.
- NCIT_C113333 NCIT_NHC0 "C113333" @default.
- NCIT_C113333 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C113333 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C113333 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C113333 NCIT_P107 "Anti-ErbB3 Monoclonal Antibody CDX-3379" @default.
- NCIT_C113333 NCIT_P108 "Anti-ErbB3 Monoclonal Antibody CDX-3379" @default.
- NCIT_C113333 NCIT_P208 "CL458161" @default.
- NCIT_C113333 NCIT_P210 "2070921-00-3" @default.
- NCIT_C113333 NCIT_P319 "00X6I56YXR" @default.
- NCIT_C113333 NCIT_P322 "CTRP" @default.
- NCIT_C113333 NCIT_P322 "FDA" @default.
- NCIT_C113333 NCIT_P322 "GDC" @default.
- NCIT_C113333 NCIT_P329 "756069" @default.
- NCIT_C113333 NCIT_P330 "756069" @default.
- NCIT_C113333 NCIT_P375 "Anti-ErbB3 Monoclonal Antibody CDX-3379" @default.
- NCIT_C113333 NCIT_P399 "756069" @default.
- NCIT_C113333 NCIT_R124 NCIT_C17710 @default.
- NCIT_C113333 NCIT_R124 NCIT_C17828 @default.
- NCIT_C113333 NCIT_R124 NCIT_C18219 @default.
- NCIT_C113333 NCIT_R124 NCIT_C19986 @default.
- NCIT_C113333 NCIT_R124 NCIT_C40474 @default.
- NCIT_C113333 normalizedInformationContent "100" @default.
- NCIT_C113333 referenceCount "1" @default.
- NCIT_C113333 hasExactSynonym "Anti-ErbB3 Monoclonal Antibody CDX-3379" @default.
- NCIT_C113333 hasExactSynonym "CDX 3379" @default.
- NCIT_C113333 hasExactSynonym "CDX-3379" @default.
- NCIT_C113333 hasExactSynonym "CDX3379" @default.
- NCIT_C113333 hasExactSynonym "KTN 3379" @default.
- NCIT_C113333 hasExactSynonym "KTN-3379" @default.
- NCIT_C113333 hasExactSynonym "KTN3379" @default.
- NCIT_C113333 inSubset NCIT_C116977 @default.
- NCIT_C113333 inSubset NCIT_C116978 @default.
- NCIT_C113333 inSubset NCIT_C128784 @default.
- NCIT_C113333 inSubset NCIT_C157711 @default.
- NCIT_C113333 inSubset NCIT_C157712 @default.
- NCIT_C113333 inSubset NCIT_C176424 @default.
- NCIT_C113333 inSubset NCIT_C177537 @default.
- NCIT_C113333 inSubset NCIT_C63923 @default.
- NCIT_C113333 type Class @default.
- NCIT_C113333 isDefinedBy ncit.owl @default.
- NCIT_C113333 label "Anti-ErbB3 Monoclonal Antibody CDX-3379" @default.
- NCIT_C113333 subClassOf NCIT_C113333 @default.
- NCIT_C113333 subClassOf NCIT_C129821 @default.
- NCIT_C113333 subClassOf NCIT_C129822 @default.
- NCIT_C113333 subClassOf NCIT_C163758 @default.
- NCIT_C113333 subClassOf NCIT_C1908 @default.
- NCIT_C113333 subClassOf NCIT_C1909 @default.
- NCIT_C113333 subClassOf NCIT_C199383 @default.
- NCIT_C113333 subClassOf NCIT_C199386 @default.
- NCIT_C113333 subClassOf NCIT_C20401 @default.
- NCIT_C113333 subClassOf NCIT_C274 @default.
- NCIT_C113333 subClassOf NCIT_C307 @default.
- NCIT_C113333 subClassOf NCIT_C308 @default.