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- NCIT_C113334 IAO_0000115 "A small molecule selective and S-adenosyl methionine (SAM) competitive inhibitor of histone-lysine N-methyltransferase EZH2, with potential antineoplastic activity. Upon administration, histone-lysine N-methyltransferase EZH2 inhibitor GSK2816126 inhibits the activity of EZH2 and specifically prevents the methylation of histone H3 lysine 27 (H3K27). This decrease in histone methylation alters gene expression patterns associated with cancer pathways and results in decreased tumor cell proliferation in cancer cells that overexpress this enzyme. EZH2, which belongs to the class of histone methyltransferases (HMTs), is overexpressed or mutated in a variety of cancers and plays a key role in tumor cell proliferation." @default.
- NCIT_C113334 NCIT_A32 NCIT_C1909 @default.
- NCIT_C113334 NCIT_A7 NCIT_C30175 @default.
- NCIT_C113334 NCIT_NHC0 "C113334" @default.
- NCIT_C113334 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C113334 NCIT_P107 "Histone-Lysine N-Methyltransferase EZH2 Inhibitor GSK2816126" @default.
- NCIT_C113334 NCIT_P108 "Histone-Lysine N-Methyltransferase EZH2 Inhibitor GSK2816126" @default.
- NCIT_C113334 NCIT_P208 "CL458162" @default.
- NCIT_C113334 NCIT_P322 "CTRP" @default.
- NCIT_C113334 NCIT_P322 "GDC" @default.
- NCIT_C113334 NCIT_P329 "756211" @default.
- NCIT_C113334 NCIT_P330 "756211" @default.
- NCIT_C113334 NCIT_P375 "Histone-Lysine N-Methyltransferase EZH2 Inhibitor GSK2816126" @default.
- NCIT_C113334 NCIT_P399 "756211" @default.
- NCIT_C113334 normalizedInformationContent "100" @default.
- NCIT_C113334 referenceCount "1" @default.
- NCIT_C113334 hasExactSynonym "EZH2 Inhibitor GSK2816126" @default.
- NCIT_C113334 hasExactSynonym "GSK2816126" @default.
- NCIT_C113334 hasExactSynonym "Histone-Lysine N-Methyltransferase EZH2 Inhibitor GSK2816126" @default.
- NCIT_C113334 inSubset NCIT_C116977 @default.
- NCIT_C113334 inSubset NCIT_C116978 @default.
- NCIT_C113334 inSubset NCIT_C128784 @default.
- NCIT_C113334 inSubset NCIT_C157711 @default.
- NCIT_C113334 inSubset NCIT_C157712 @default.
- NCIT_C113334 inSubset NCIT_C176424 @default.
- NCIT_C113334 inSubset NCIT_C177537 @default.
- NCIT_C113334 type Class @default.
- NCIT_C113334 isDefinedBy ncit.owl @default.
- NCIT_C113334 label "Histone-Lysine N-Methyltransferase EZH2 Inhibitor GSK2816126" @default.
- NCIT_C113334 subClassOf NCIT_C113334 @default.
- NCIT_C113334 subClassOf NCIT_C129824 @default.
- NCIT_C113334 subClassOf NCIT_C129825 @default.
- NCIT_C113334 subClassOf NCIT_C156804 @default.
- NCIT_C113334 subClassOf NCIT_C1908 @default.
- NCIT_C113334 subClassOf NCIT_C1909 @default.
- NCIT_C113334 subClassOf NCIT_C2189 @default.
- NCIT_C113334 subClassOf NCIT_C274 @default.
- NCIT_C113334 subClassOf NCIT_C471 @default.