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- NCIT_C113432 IAO_0000115 "A cancer vaccine composed of a recombinant form of the tumor antigen NY-ESO-1 and glucopyranosyl lipid adjuvant (GLA)-stable emulsion (GLA-SE), with potential antineoplastic and immunomodulating activities. Upon intramuscular injection, the adjuvant portion of the NY-ESO-1/GLA-SE vaccine ID-G30 binds to toll-like receptor subtype 4 (TLR-4) expressed on dendritic cells (DCs), monocytes, macrophages and B cells. The activated DCs present the NY-ESO-1 antigen to Th1 CD4 T-lymphocytes. This leads to the induction of cytotoxic T lymphocytes (CTLs) and the killing of NY-ESO-1-expressing tumor cells. This vaccine also induces specific antibody responses and increases the production of inflammatory cytokines." @default.
- NCIT_C113432 NCIT_A32 NCIT_C1909 @default.
- NCIT_C113432 NCIT_NHC0 "C113432" @default.
- NCIT_C113432 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C113432 NCIT_P107 "NY-ESO-1/GLA-SE Vaccine ID-G305" @default.
- NCIT_C113432 NCIT_P108 "NY-ESO-1/GLA-SE Vaccine ID-G305" @default.
- NCIT_C113432 NCIT_P208 "CL458226" @default.
- NCIT_C113432 NCIT_P322 "CTRP" @default.
- NCIT_C113432 NCIT_P322 "GDC" @default.
- NCIT_C113432 NCIT_P329 "756236" @default.
- NCIT_C113432 NCIT_P330 "756236" @default.
- NCIT_C113432 NCIT_P375 "NY-ESO-1/GLA-SE Vaccine ID-G305" @default.
- NCIT_C113432 NCIT_P399 "756236" @default.
- NCIT_C113432 normalizedInformationContent "100" @default.
- NCIT_C113432 referenceCount "1" @default.
- NCIT_C113432 hasExactSynonym "ID-G305" @default.
- NCIT_C113432 hasExactSynonym "IDC-G305" @default.
- NCIT_C113432 hasExactSynonym "NY-ESO-1/GLA-SE Vaccine ID-G305" @default.
- NCIT_C113432 inSubset NCIT_C116977 @default.
- NCIT_C113432 inSubset NCIT_C116978 @default.
- NCIT_C113432 inSubset NCIT_C128784 @default.
- NCIT_C113432 inSubset NCIT_C157711 @default.
- NCIT_C113432 inSubset NCIT_C157712 @default.
- NCIT_C113432 inSubset NCIT_C176424 @default.
- NCIT_C113432 inSubset NCIT_C177537 @default.
- NCIT_C113432 type Class @default.
- NCIT_C113432 isDefinedBy ncit.owl @default.
- NCIT_C113432 label "NY-ESO-1/GLA-SE Vaccine ID-G305" @default.
- NCIT_C113432 subClassOf NCIT_C113432 @default.
- NCIT_C113432 subClassOf NCIT_C129820 @default.
- NCIT_C113432 subClassOf NCIT_C1663 @default.
- NCIT_C113432 subClassOf NCIT_C1908 @default.
- NCIT_C113432 subClassOf NCIT_C1909 @default.
- NCIT_C113432 subClassOf NCIT_C274 @default.
- NCIT_C113432 subClassOf NCIT_C307 @default.
- NCIT_C113432 subClassOf NCIT_C308 @default.
- NCIT_C113432 subClassOf NCIT_C923 @default.