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- NCIT_C113437 IAO_0000115 "A synthetic, 5-amino acid peptide and Innate Defense Regulator (IDR), with immunomodulating, anti-inflammatory, anti-infective and anti-mucositis activities. Upon intravenous administration, dusquetide binds to the ZZ domain of sequestosome-1, also called p62, and activates regulatory signaling transduction pathways involved in the modulation of the innate immune system, such as those mediated by mitogen-activated protein kinase (MAPK) p38 and CCAAT-enhancer-binding protein. This agent promotes monocyte and macrophage recruitment to, and accelerates healing in damaged and infected tissue; it suppresses inflammation through the regulation of the expression of multiple cytokines. This agent may prevent or decrease chemo- or radiotherapy-induced mucositis as well as other types of infection. p62, an intracellular adaptor protein that functions downstream of certain signaling receptors, plays a key role in the activation of the innate immune system." @default.
- NCIT_C113437 NCIT_A7 NCIT_C101493 @default.
- NCIT_C113437 NCIT_NHC0 "C113437" @default.
- NCIT_C113437 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C113437 NCIT_P107 "Innate Defense Regulator SGX942" @default.
- NCIT_C113437 NCIT_P108 "Dusquetide" @default.
- NCIT_C113437 NCIT_P208 "CL458231" @default.
- NCIT_C113437 NCIT_P210 "931395-42-5" @default.
- NCIT_C113437 NCIT_P319 "IKX7W49NLN" @default.
- NCIT_C113437 NCIT_P322 "CTRP" @default.
- NCIT_C113437 NCIT_P322 "FDA" @default.
- NCIT_C113437 NCIT_P329 "756272" @default.
- NCIT_C113437 NCIT_P330 "756272" @default.
- NCIT_C113437 NCIT_P399 "756272" @default.
- NCIT_C113437 normalizedInformationContent "100" @default.
- NCIT_C113437 referenceCount "1" @default.
- NCIT_C113437 hasExactSynonym "DUSQUETIDE" @default.
- NCIT_C113437 hasExactSynonym "Dusquetide" @default.
- NCIT_C113437 hasExactSynonym "IMX 942" @default.
- NCIT_C113437 hasExactSynonym "Innate Defense Regulator SGX942" @default.
- NCIT_C113437 hasExactSynonym "L-Alaninamide, L-arginyl-L-isoleucyl-L-valyl-L-prolyl-" @default.
- NCIT_C113437 hasExactSynonym "SGX942" @default.
- NCIT_C113437 inSubset NCIT_C116977 @default.
- NCIT_C113437 inSubset NCIT_C116978 @default.
- NCIT_C113437 inSubset NCIT_C176424 @default.
- NCIT_C113437 inSubset NCIT_C63923 @default.
- NCIT_C113437 type Class @default.
- NCIT_C113437 isDefinedBy ncit.owl @default.
- NCIT_C113437 label "Dusquetide" @default.
- NCIT_C113437 subClassOf NCIT_C113437 @default.
- NCIT_C113437 subClassOf NCIT_C1908 @default.
- NCIT_C113437 subClassOf NCIT_C1909 @default.
- NCIT_C113437 subClassOf NCIT_C308 @default.
- NCIT_C113437 subClassOf NCIT_C574 @default.