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- NCIT_C113441 IAO_0000115 "A radioconjugate consisting of a lipophilic, neutral, bioreductive copper-bis(thiosemicarbazone) complex, copper-diacetyl-bis(N4-methylthiosemicarbazone) (Cu-ATSM), labeled with the beta-emitting radioisotope copper Cu 62, with hypoxia-selective and positron emitting tomography (PET) radioimaging activities. With a high membrane permeability and low reduction potential, copper Cu 62-ATSM easily enters cells. This agent can only be reduced by mitochondria found in hypoxic cells with abnormally high electron concentrations. This chemical reaction traps Cu 62-ATSM in the cell, which allows for the selective accumulation of this agent in hypoxic cells compared to normoxic cells. The extent of copper Cu 62-ATSM retention in tissue is inversely related to the state of tissue oxygenation allowing the quantitation of tissue hypoxia with PET. This provides information about diagnosis, prognosis, treatment options and outcomes for certain cancers. The short half-life of copper Cu 62 (9.7 minutes) reduces the amount of radiation a patient is subjected to and allows for several imaging studies to be performed. Hypoxic tumors are associated with increased malignancy and resistance to radiation and chemotherapy." @default.
- NCIT_C113441 NCIT_NHC0 "C113441" @default.
- NCIT_C113441 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C113441 NCIT_P107 "Copper Cu 62-ATSM" @default.
- NCIT_C113441 NCIT_P108 "Copper Cu 62-ATSM" @default.
- NCIT_C113441 NCIT_P208 "CL458235" @default.
- NCIT_C113441 NCIT_P322 "CTRP" @default.
- NCIT_C113441 NCIT_P329 "756429" @default.
- NCIT_C113441 NCIT_P330 "756429" @default.
- NCIT_C113441 NCIT_P399 "756429" @default.
- NCIT_C113441 normalizedInformationContent "100" @default.
- NCIT_C113441 referenceCount "1" @default.
- NCIT_C113441 hasExactSynonym "62Cu-ATSM" @default.
- NCIT_C113441 hasExactSynonym "Copper Cu 62-ATSM" @default.
- NCIT_C113441 inSubset NCIT_C116977 @default.
- NCIT_C113441 inSubset NCIT_C116978 @default.
- NCIT_C113441 inSubset NCIT_C176424 @default.
- NCIT_C113441 type Class @default.
- NCIT_C113441 isDefinedBy ncit.owl @default.
- NCIT_C113441 label "Copper Cu 62-ATSM" @default.
- NCIT_C113441 subClassOf NCIT_C113441 @default.
- NCIT_C113441 subClassOf NCIT_C1446 @default.
- NCIT_C113441 subClassOf NCIT_C1908 @default.
- NCIT_C113441 subClassOf NCIT_C1909 @default.
- NCIT_C113441 subClassOf NCIT_C2124 @default.