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- NCIT_C113443 IAO_0000115 "A member of the synthetic oleanane triterpenoid class of compounds and an activator of nuclear factor erythroid 2 [NF-E2]-related factor 2 (Nrf2, Nfe2l2), with potential chemopreventive activity. Upon administration, omaveloxolone activates the cytoprotective transcription factor Nrf2. In turn, Nrf2 translocates to the nucleus, dimerizes with a small Maf protein (sMaf), and binds to the antioxidant response element (ARE). This induces the expression of a number of cytoprotective genes, including NAD(P)H quinone oxidoreductase 1 (NQO1), sulfiredoxin 1 (Srxn1), heme oxygenase-1 (HO1, HMOX1), superoxide dismutase 1 (SOD1), gamma-glutamylcysteine synthetase (gamma-GCS), thioredoxin reductase-1 (TXNRD1), glutathione S-transferase (GST), glutamate-cysteine ligase catalytic subunit (Gclc) and glutamate-cysteine ligase regulatory subunit (Gclm), and increases the synthesis of the antioxidant glutathione (GSH). Nrf2, a leucine zipper transcription factor, plays a key role in the maintenance of redox balance and cytoprotection against oxidative stress." @default.
- NCIT_C113443 NCIT_NHC0 "C113443" @default.
- NCIT_C113443 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C113443 NCIT_P107 "Omaveloxolone" @default.
- NCIT_C113443 NCIT_P108 "Omaveloxolone" @default.
- NCIT_C113443 NCIT_P207 "C3827059" @default.
- NCIT_C113443 NCIT_P210 "1474034-05-3" @default.
- NCIT_C113443 NCIT_P319 "G69Z98951Q" @default.
- NCIT_C113443 NCIT_P322 "CTRP" @default.
- NCIT_C113443 NCIT_P322 "FDA" @default.
- NCIT_C113443 NCIT_P329 "756624" @default.
- NCIT_C113443 NCIT_P330 "756624" @default.
- NCIT_C113443 NCIT_P399 "756624" @default.
- NCIT_C113443 normalizedInformationContent "100" @default.
- NCIT_C113443 referenceCount "1" @default.
- NCIT_C113443 hasExactSynonym "OMAVELOXOLONE" @default.
- NCIT_C113443 hasExactSynonym "Omaveloxolone" @default.
- NCIT_C113443 hasExactSynonym "Propanamide, N-(2-cyano-3,12-dioxo-28-noroleana-1,9(11)-dien-17-yl)-2,2-difluoro-" @default.
- NCIT_C113443 hasExactSynonym "RTA 408" @default.
- NCIT_C113443 hasExactSynonym "RTA-408" @default.
- NCIT_C113443 inSubset NCIT_C116977 @default.
- NCIT_C113443 inSubset NCIT_C116978 @default.
- NCIT_C113443 inSubset NCIT_C176424 @default.
- NCIT_C113443 inSubset NCIT_C63923 @default.
- NCIT_C113443 type Class @default.
- NCIT_C113443 isDefinedBy ncit.owl @default.
- NCIT_C113443 label "Omaveloxolone" @default.
- NCIT_C113443 subClassOf NCIT_C113443 @default.
- NCIT_C113443 subClassOf NCIT_C1908 @default.
- NCIT_C113443 subClassOf NCIT_C1909 @default.
- NCIT_C113443 subClassOf NCIT_C2080 @default.
- NCIT_C113443 subClassOf NCIT_C2459 @default.
- NCIT_C113443 subClassOf NCIT_C26170 @default.