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- NCIT_C113656 IAO_0000115 "A long-acting release (LAR) formulation containing pasireotide, a synthetic long-acting cyclohexapeptide, with somatostatin-like activity. Upon intramuscular administration of the LAR formulation of pasireotide, this somatostatin analog strongly binds to and activates somatostatin receptor (SSTR) subtypes 1, 2, 3, and 5. This leads to an inhibition in the secretion of human growth hormone (hGH) and results in decreased production of insulin-like growth factor (IGF-1), which may inhibit IGF-1-mediated cell signaling pathways. This may lead to an inhibition in tumor cell growth and an increase in apoptosis in IGF-1-overexpressing tumor cells. In addition, this agent causes a reduction in adrenocorticotropic hormone (ACTH), which leads to an inhibition of cortisol secretion. ACTH-producing tumors cause hypersecretion of cortisol which results in many unwanted symptoms. This agent may also block other key survival pathways such as the phosphatidylinositol 3-kinase (PI3K) and the mitogen-activated protein kinase (MAPK) signaling pathways. Pasireotide also inhibits vascular endothelial growth factor (VEGF) secretion, thereby decreasing angiogenesis and tumor cell growth in VEGF-overexpressing tumor cells. The long-acting form of pasireotide allows for less frequent administration as compared to the original form of this agent. SSTRs are overexpressed by some neuroendocrine and non-neuroendocrine tumor cells." @default.
- NCIT_C113656 NCIT_A32 NCIT_C1909 @default.
- NCIT_C113656 NCIT_A7 NCIT_C17922 @default.
- NCIT_C113656 NCIT_A7 NCIT_C17927 @default.
- NCIT_C113656 NCIT_A7 NCIT_C18035 @default.
- NCIT_C113656 NCIT_A7 NCIT_C18043 @default.
- NCIT_C113656 NCIT_NHC0 "C113656" @default.
- NCIT_C113656 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C113656 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C113656 NCIT_P107 "Long-acting Release Pasireotide" @default.
- NCIT_C113656 NCIT_P108 "Long-acting Release Pasireotide" @default.
- NCIT_C113656 NCIT_P208 "CL458369" @default.
- NCIT_C113656 NCIT_P322 "CTRP" @default.
- NCIT_C113656 NCIT_P322 "GDC" @default.
- NCIT_C113656 NCIT_P329 "756940" @default.
- NCIT_C113656 NCIT_P330 "756940" @default.
- NCIT_C113656 NCIT_P375 "Long-acting Release Pasireotide" @default.
- NCIT_C113656 NCIT_P399 "756940" @default.
- NCIT_C113656 normalizedInformationContent "100" @default.
- NCIT_C113656 referenceCount "1" @default.
- NCIT_C113656 hasExactSynonym "LAR Pasireotide" @default.
- NCIT_C113656 hasExactSynonym "Long-acting Release Pasireotide" @default.
- NCIT_C113656 hasExactSynonym "SOM230 LAR" @default.
- NCIT_C113656 inSubset NCIT_C116977 @default.
- NCIT_C113656 inSubset NCIT_C116978 @default.
- NCIT_C113656 inSubset NCIT_C128784 @default.
- NCIT_C113656 inSubset NCIT_C157711 @default.
- NCIT_C113656 inSubset NCIT_C157712 @default.
- NCIT_C113656 inSubset NCIT_C176424 @default.
- NCIT_C113656 inSubset NCIT_C177537 @default.
- NCIT_C113656 type Class @default.
- NCIT_C113656 isDefinedBy ncit.owl @default.
- NCIT_C113656 label "Long-acting Release Pasireotide" @default.
- NCIT_C113656 subClassOf NCIT_C113656 @default.
- NCIT_C113656 subClassOf NCIT_C147908 @default.
- NCIT_C113656 subClassOf NCIT_C1908 @default.
- NCIT_C113656 subClassOf NCIT_C1909 @default.
- NCIT_C113656 subClassOf NCIT_C548 @default.
- NCIT_C113656 subClassOf NCIT_C62799 @default.