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- NCIT_C113659 IAO_0000115 "A humanized, monoclonal antibody targeting the CD98 (gp125) antigen, with potential immunomodulatory and antineoplastic activities. Upon intravenous administration, IGN523 binds to CD98 expressed on the tumor cell surface and elicits both natural killer (NK)-cell mediated antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity towards CD98-expressing tumor cells. In addition, IGN523 inhibits essential amino acid uptake by rapidly proliferating tumor cells. CD98, a type II transmembrane glycoprotein, is involved in both integrin signaling and amino acid transport processes; it is overexpressed in certain cancer cells and plays a key role in the proliferation, survival and metastasis of tumor cells." @default.
- NCIT_C113659 NCIT_A32 NCIT_C1909 @default.
- NCIT_C113659 NCIT_NHC0 "C113659" @default.
- NCIT_C113659 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C113659 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C113659 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C113659 NCIT_P108 "Anti-CD98 Monoclonal Antibody IGN523" @default.
- NCIT_C113659 NCIT_P208 "CL458372" @default.
- NCIT_C113659 NCIT_P210 "2206820-08-6" @default.
- NCIT_C113659 NCIT_P319 "7OI79TB6KN" @default.
- NCIT_C113659 NCIT_P322 "FDA" @default.
- NCIT_C113659 NCIT_P322 "GDC" @default.
- NCIT_C113659 NCIT_P329 "757070" @default.
- NCIT_C113659 NCIT_P330 "757070" @default.
- NCIT_C113659 NCIT_P375 "Anti-CD98 Monoclonal Antibody IGN523" @default.
- NCIT_C113659 NCIT_P399 "757070" @default.
- NCIT_C113659 NCIT_R124 NCIT_C17710 @default.
- NCIT_C113659 NCIT_R124 NCIT_C17828 @default.
- NCIT_C113659 NCIT_R124 NCIT_C18219 @default.
- NCIT_C113659 NCIT_R124 NCIT_C19986 @default.
- NCIT_C113659 NCIT_R124 NCIT_C40474 @default.
- NCIT_C113659 normalizedInformationContent "100" @default.
- NCIT_C113659 referenceCount "1" @default.
- NCIT_C113659 hasExactSynonym "Anti-CD98 Monoclonal Antibody IGN523" @default.
- NCIT_C113659 hasExactSynonym "IGN-523" @default.
- NCIT_C113659 hasExactSynonym "IGN523" @default.
- NCIT_C113659 inSubset NCIT_C128784 @default.
- NCIT_C113659 inSubset NCIT_C157711 @default.
- NCIT_C113659 inSubset NCIT_C157712 @default.
- NCIT_C113659 inSubset NCIT_C176424 @default.
- NCIT_C113659 inSubset NCIT_C177537 @default.
- NCIT_C113659 inSubset NCIT_C63923 @default.
- NCIT_C113659 type Class @default.
- NCIT_C113659 isDefinedBy ncit.owl @default.
- NCIT_C113659 label "Anti-CD98 Monoclonal Antibody IGN523" @default.
- NCIT_C113659 subClassOf NCIT_C113659 @default.
- NCIT_C113659 subClassOf NCIT_C129821 @default.
- NCIT_C113659 subClassOf NCIT_C129822 @default.
- NCIT_C113659 subClassOf NCIT_C1908 @default.
- NCIT_C113659 subClassOf NCIT_C1909 @default.
- NCIT_C113659 subClassOf NCIT_C20401 @default.
- NCIT_C113659 subClassOf NCIT_C274 @default.
- NCIT_C113659 subClassOf NCIT_C307 @default.
- NCIT_C113659 subClassOf NCIT_C308 @default.