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- NCIT_C113786 IAO_0000115 "A complex, replication-selective, chimeric adenovirus type 11p (Ad11p)/Ad3 oncolytic virus vaccine, with potential antineoplastic and immunomodulating activities. Enadenotucirev has the Ad11p backbone with a large deletion in the E3-region and a small E4-domain (E4orf4) deleted, in addition to a partial E2B substitution by the Ad3 E2B genes. Upon intravenous administration of enadenotucirev, the adenovirus selectively reaches the tumor cells due to the leaky tumor vasculature and replicates in cancer cells; however, it is unable to replicate in normal, healthy cells. This induces a selective adenovirus-mediated cytotoxicity in cancer cells, which leads to cancer lysis. Following the lysis of infected cells, the replicated virus is released and can infect adjacent cells, which both induces further tumor cell oncolysis and may activate, through the release of tumor-associated antigens (TAAs) and inflammatory mediators from the lysed tumor cells, the immune system to mount an anti-tumor immune response. This further kills tumor cells. This may also stimulate long-term anti-tumor immunity. Although the cancer-selectivity of enadenotucirev is not entirely understood, the virus does not efficiently infect normal cells." @default.
- NCIT_C113786 NCIT_A32 NCIT_C1909 @default.
- NCIT_C113786 NCIT_NHC0 "C113786" @default.
- NCIT_C113786 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C113786 NCIT_P107 "Enadenotucirev" @default.
- NCIT_C113786 NCIT_P108 "Enadenotucirev" @default.
- NCIT_C113786 NCIT_P208 "CL471767" @default.
- NCIT_C113786 NCIT_P210 "1402042-02-7" @default.
- NCIT_C113786 NCIT_P319 "KX7ZYR6OQW" @default.
- NCIT_C113786 NCIT_P322 "CTRP" @default.
- NCIT_C113786 NCIT_P322 "FDA" @default.
- NCIT_C113786 NCIT_P322 "GDC" @default.
- NCIT_C113786 NCIT_P329 "757141" @default.
- NCIT_C113786 NCIT_P330 "757141" @default.
- NCIT_C113786 NCIT_P375 "Enadenotucirev" @default.
- NCIT_C113786 NCIT_P399 "757141" @default.
- NCIT_C113786 normalizedInformationContent "100" @default.
- NCIT_C113786 referenceCount "1" @default.
- NCIT_C113786 hasExactSynonym "Chimeric Oncolytic Adenovirus Ad3/Ad11p Containing Two Deletions in the Viral Genome in the E3 Region (2444 bp) and in the E4 Region (24 bp) and 197 Non-homologous Nucleotides in the E2B Region" @default.
- NCIT_C113786 hasExactSynonym "ColoAd-1" @default.
- NCIT_C113786 hasExactSynonym "ColoAd1 Oncolytic Virus" @default.
- NCIT_C113786 hasExactSynonym "ColoAd1" @default.
- NCIT_C113786 hasExactSynonym "ENADENOTUCIREV" @default.
- NCIT_C113786 hasExactSynonym "EnAd" @default.
- NCIT_C113786 hasExactSynonym "Enadenotucirev" @default.
- NCIT_C113786 inSubset NCIT_C116977 @default.
- NCIT_C113786 inSubset NCIT_C116978 @default.
- NCIT_C113786 inSubset NCIT_C128784 @default.
- NCIT_C113786 inSubset NCIT_C157711 @default.
- NCIT_C113786 inSubset NCIT_C157712 @default.
- NCIT_C113786 inSubset NCIT_C176424 @default.
- NCIT_C113786 inSubset NCIT_C177537 @default.
- NCIT_C113786 inSubset NCIT_C63923 @default.
- NCIT_C113786 type Class @default.
- NCIT_C113786 isDefinedBy ncit.owl @default.
- NCIT_C113786 label "Enadenotucirev" @default.
- NCIT_C113786 subClassOf NCIT_C113786 @default.
- NCIT_C113786 subClassOf NCIT_C129821 @default.
- NCIT_C113786 subClassOf NCIT_C1572 @default.
- NCIT_C113786 subClassOf NCIT_C1908 @default.
- NCIT_C113786 subClassOf NCIT_C1909 @default.
- NCIT_C113786 subClassOf NCIT_C274 @default.
- NCIT_C113786 subClassOf NCIT_C307 @default.
- NCIT_C113786 subClassOf NCIT_C308 @default.
- NCIT_C113786 subClassOf NCIT_C49146 @default.
- NCIT_C113786 subClassOf NCIT_C717 @default.
- NCIT_C113786 subClassOf NCIT_C923 @default.
- NCIT_C113786 subClassOf NCIT_C96404 @default.