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- NCIT_C113787 IAO_0000115 "An inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFK-2/FBPase) isoform 3 (PFKFB3) and derivative of 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO), with potential antineoplastic activity. Upon administration, PFKFB3 inhibitor PFK-158 binds to and inhibits the activity of PFKFB3, which leads to the inhibition of both the glycolytic pathway in and glucose uptake by cancer cells. This prevents the production of macromolecules and energy that causes the enhanced cellular proliferation in cancer cells as compared to that of normal, healthy cells. Depriving cancer cells of nutrients and energy leads to the inhibition of cancer cell growth. PFKFB3, an enzyme that catalyzes the conversion of fructose-6-phosphate to fructose-2,6-bisphosphate, is highly expressed and active in human cancer cells; it plays a key role in increasing both glycolytic flux in and proliferation of cancer cells." @default.
- NCIT_C113787 NCIT_A32 NCIT_C1909 @default.
- NCIT_C113787 NCIT_NHC0 "C113787" @default.
- NCIT_C113787 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C113787 NCIT_P108 "6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatases Isoform 3 Inhibitor ACT-PFK-158" @default.
- NCIT_C113787 NCIT_P208 "CL471768" @default.
- NCIT_C113787 NCIT_P322 "GDC" @default.
- NCIT_C113787 NCIT_P329 "757225" @default.
- NCIT_C113787 NCIT_P330 "757225" @default.
- NCIT_C113787 NCIT_P375 "6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatases Isoform 3 Inhibitor ACT-PFK-158" @default.
- NCIT_C113787 NCIT_P399 "757225" @default.
- NCIT_C113787 normalizedInformationContent "100" @default.
- NCIT_C113787 referenceCount "1" @default.
- NCIT_C113787 hasExactSynonym "6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatases Isoform 3 Inhibitor ACT-PFK-158" @default.
- NCIT_C113787 hasExactSynonym "ACT-PFK-158" @default.
- NCIT_C113787 hasExactSynonym "PFK-158" @default.
- NCIT_C113787 hasExactSynonym "PFKFB3 Inhibitor PFK-158" @default.
- NCIT_C113787 inSubset NCIT_C128784 @default.
- NCIT_C113787 inSubset NCIT_C157711 @default.
- NCIT_C113787 inSubset NCIT_C157712 @default.
- NCIT_C113787 inSubset NCIT_C176424 @default.
- NCIT_C113787 inSubset NCIT_C177537 @default.
- NCIT_C113787 type Class @default.
- NCIT_C113787 isDefinedBy ncit.owl @default.
- NCIT_C113787 label "6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatases Isoform 3 Inhibitor ACT-PFK-158" @default.
- NCIT_C113787 subClassOf NCIT_C113787 @default.
- NCIT_C113787 subClassOf NCIT_C1908 @default.
- NCIT_C113787 subClassOf NCIT_C1909 @default.
- NCIT_C113787 subClassOf NCIT_C471 @default.