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- NCIT_C113788 IAO_0000115 "A small molecule inhibitor of ubiquitin-activating enzyme (UAE), with potential antineoplastic activity. UAE inhibitor TAK-243 binds to and inhibits UAE, which prevents both protein ubiquitination and subsequent protein degradation by the proteasome. This results in an excess of proteins in the cells and may lead to endoplasmic reticulum (ER) stress-mediated apoptosis. This inhibits tumor cell proliferation and survival. UAE, also called ubiquitin E1 enzyme (UBA1; E1), is more active in cancer cells than in normal, healthy cells." @default.
- NCIT_C113788 NCIT_A32 NCIT_C1909 @default.
- NCIT_C113788 NCIT_A7 NCIT_C133714 @default.
- NCIT_C113788 NCIT_NHC0 "C113788" @default.
- NCIT_C113788 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C113788 NCIT_P107 "UAE Inhibitor TAK-243" @default.
- NCIT_C113788 NCIT_P108 "UAE Inhibitor TAK-243" @default.
- NCIT_C113788 NCIT_P208 "CL471769" @default.
- NCIT_C113788 NCIT_P210 "1450833-55-2" @default.
- NCIT_C113788 NCIT_P319 "V9GGV0YCDI" @default.
- NCIT_C113788 NCIT_P322 "CTRP" @default.
- NCIT_C113788 NCIT_P322 "FDA" @default.
- NCIT_C113788 NCIT_P322 "GDC" @default.
- NCIT_C113788 NCIT_P329 "757275" @default.
- NCIT_C113788 NCIT_P330 "757275" @default.
- NCIT_C113788 NCIT_P375 "UAE Inhibitor TAK-243" @default.
- NCIT_C113788 NCIT_P399 "757275" @default.
- NCIT_C113788 normalizedInformationContent "100" @default.
- NCIT_C113788 referenceCount "1" @default.
- NCIT_C113788 hasExactSynonym "AOB87172" @default.
- NCIT_C113788 hasExactSynonym "MLN7243" @default.
- NCIT_C113788 hasExactSynonym "TAK-243" @default.
- NCIT_C113788 hasExactSynonym "UAE Inhibitor TAK-243" @default.
- NCIT_C113788 inSubset NCIT_C116977 @default.
- NCIT_C113788 inSubset NCIT_C116978 @default.
- NCIT_C113788 inSubset NCIT_C128784 @default.
- NCIT_C113788 inSubset NCIT_C157711 @default.
- NCIT_C113788 inSubset NCIT_C157712 @default.
- NCIT_C113788 inSubset NCIT_C176424 @default.
- NCIT_C113788 inSubset NCIT_C177537 @default.
- NCIT_C113788 inSubset NCIT_C63923 @default.
- NCIT_C113788 type Class @default.
- NCIT_C113788 isDefinedBy ncit.owl @default.
- NCIT_C113788 label "UAE Inhibitor TAK-243" @default.
- NCIT_C113788 subClassOf NCIT_C113788 @default.
- NCIT_C113788 subClassOf NCIT_C1908 @default.
- NCIT_C113788 subClassOf NCIT_C1909 @default.
- NCIT_C113788 subClassOf NCIT_C471 @default.