Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C113789> ?p ?o ?g. }
Showing items 1 to 37 of
37
with 100 items per page.
- NCIT_C113789 IAO_0000115 "A conjugate containing the antimetabolite and antifolate agent methotrexate conjugated to insulin-like growth factor (IGF), with potential antineoplastic activity. After intravenous administration, the IGF moiety of the IGF-methotrexate conjugate binds to and is internalized by IGF receptors (IGFR) on the surface of tumor cells. Following cell entry, the methotrexate then binds to and inhibits the enzyme dihydrofolate reductase, which catalyzes the conversion of dihydrofolate to tetrahydrofolate. This results in both the inhibition of DNA and RNA synthesis and the induction of death in rapidly dividing cells. Binding to IGFR can localize the cytotoxic effect of methotrexate in tumor cells. This may increase its efficacy while decreasing its toxicity to normal, healthy cells. IGFR is overexpressed on many types of cancer cells and has been implicated in metastasis and resistance to apoptosis." @default.
- NCIT_C113789 NCIT_A32 NCIT_C1909 @default.
- NCIT_C113789 NCIT_A7 NCIT_C17191 @default.
- NCIT_C113789 NCIT_A7 NCIT_C17531 @default.
- NCIT_C113789 NCIT_NHC0 "C113789" @default.
- NCIT_C113789 NCIT_P106 "Organic Chemical" @default.
- NCIT_C113789 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C113789 NCIT_P107 "IGF-methotrexate Conjugate" @default.
- NCIT_C113789 NCIT_P108 "IGF-methotrexate Conjugate" @default.
- NCIT_C113789 NCIT_P208 "CL471770" @default.
- NCIT_C113789 NCIT_P322 "CTRP" @default.
- NCIT_C113789 NCIT_P322 "GDC" @default.
- NCIT_C113789 NCIT_P329 "757276" @default.
- NCIT_C113789 NCIT_P330 "757276" @default.
- NCIT_C113789 NCIT_P375 "IGF-methotrexate Conjugate" @default.
- NCIT_C113789 NCIT_P399 "757276" @default.
- NCIT_C113789 normalizedInformationContent "100" @default.
- NCIT_C113789 referenceCount "1" @default.
- NCIT_C113789 hasExactSynonym "765IGF-MTX" @default.
- NCIT_C113789 hasExactSynonym "IGF-methotrexate Conjugate" @default.
- NCIT_C113789 hasExactSynonym "IGF/MTX Conjugate" @default.
- NCIT_C113789 hasExactSynonym "IGF/MTX" @default.
- NCIT_C113789 inSubset NCIT_C116977 @default.
- NCIT_C113789 inSubset NCIT_C116978 @default.
- NCIT_C113789 inSubset NCIT_C128784 @default.
- NCIT_C113789 inSubset NCIT_C157711 @default.
- NCIT_C113789 inSubset NCIT_C157712 @default.
- NCIT_C113789 inSubset NCIT_C176424 @default.
- NCIT_C113789 inSubset NCIT_C177537 @default.
- NCIT_C113789 type Class @default.
- NCIT_C113789 isDefinedBy ncit.owl @default.
- NCIT_C113789 label "IGF-methotrexate Conjugate" @default.
- NCIT_C113789 subClassOf NCIT_C113789 @default.
- NCIT_C113789 subClassOf NCIT_C1908 @default.
- NCIT_C113789 subClassOf NCIT_C1909 @default.
- NCIT_C113789 subClassOf NCIT_C2153 @default.
- NCIT_C113789 subClassOf NCIT_C471 @default.