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- NCIT_C113790 IAO_0000115 "An oncolytic, replication-competent adenovirus encoding the human glycosylphosphatidylinositol-anchored enzyme PH20 hyaluronidase with potential antitumor activity. After intratumoral administration, PH20 hyaluronidase-expressing adenovirus VCN-01 selectively replicates in tumor cells, which may both cause oncolytic virus-induced cell death and induce the infection of adjacent tumor cells. In addition, the virus expresses hyaluronidase, which hydrolyzes and degrades the hyaluronic acid (HA) that coats tumor cells. The degradation of HA may result in a decrease for both the viscosity of the interstitial space and the tumor's interstitial fluid pressure (IFP). This increases viral spread and may result in the inhibition of tumor cell growth. In addition, HA degradation facilitates the penetration of chemotherapeutic agents into the tumor. HA is a glycosaminoglycan found in the extracellular matrix (ECM) and is frequently overproduced by various tumor cell types. The presence of HA in tumors correlates with increases in tumor cell growth, metastatic potential, tumor progression and resistance to chemotherapeutic agents." @default.
- NCIT_C113790 NCIT_A32 NCIT_C1909 @default.
- NCIT_C113790 NCIT_NHC0 "C113790" @default.
- NCIT_C113790 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C113790 NCIT_P107 "PH20 Hyaluronidase-expressing Adenovirus VCN-01" @default.
- NCIT_C113790 NCIT_P108 "PH20 Hyaluronidase-expressing Adenovirus VCN-01" @default.
- NCIT_C113790 NCIT_P208 "CL471771" @default.
- NCIT_C113790 NCIT_P322 "CTRP" @default.
- NCIT_C113790 NCIT_P322 "GDC" @default.
- NCIT_C113790 NCIT_P329 "757334" @default.
- NCIT_C113790 NCIT_P330 "757334" @default.
- NCIT_C113790 NCIT_P375 "PH20 Hyaluronidase-expressing Adenovirus VCN-01" @default.
- NCIT_C113790 NCIT_P399 "757334" @default.
- NCIT_C113790 normalizedInformationContent "100" @default.
- NCIT_C113790 referenceCount "1" @default.
- NCIT_C113790 hasExactSynonym "Genetically Modified Adenovirus-encoding Human PH20 Hyaluronidase VCN-01" @default.
- NCIT_C113790 hasExactSynonym "PH20 Hyaluronidase-expressing Adenovirus VCN-01" @default.
- NCIT_C113790 hasExactSynonym "VCN-01" @default.
- NCIT_C113790 inSubset NCIT_C116977 @default.
- NCIT_C113790 inSubset NCIT_C116978 @default.
- NCIT_C113790 inSubset NCIT_C128784 @default.
- NCIT_C113790 inSubset NCIT_C157711 @default.
- NCIT_C113790 inSubset NCIT_C157712 @default.
- NCIT_C113790 inSubset NCIT_C176424 @default.
- NCIT_C113790 inSubset NCIT_C177537 @default.
- NCIT_C113790 type Class @default.
- NCIT_C113790 isDefinedBy ncit.owl @default.
- NCIT_C113790 label "PH20 Hyaluronidase-expressing Adenovirus VCN-01" @default.
- NCIT_C113790 subClassOf NCIT_C113790 @default.
- NCIT_C113790 subClassOf NCIT_C1908 @default.
- NCIT_C113790 subClassOf NCIT_C1909 @default.
- NCIT_C113790 subClassOf NCIT_C1962 @default.
- NCIT_C113790 subClassOf NCIT_C2140 @default.
- NCIT_C113790 subClassOf NCIT_C307 @default.