Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C113792> ?p ?o ?g. }
Showing items 1 to 43 of
43
with 100 items per page.
- NCIT_C113792 IAO_0000115 "A water soluble, orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) and extracellular signal-regulated kinase (ERK), with potential antineoplastic activity. Upon administration, dordaviprone binds to and inhibits the activity of Akt and ERK, which may result in inhibition of the phosphatidylinositol 3-kinase (PI3K)/Akt signal transduction pathway as well as the mitogen-activated protein kinase (MAPK)/ERK-mediated pathway. This may lead to the induction of tumor cell apoptosis mediated by tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)/TRAIL death receptor type 5 (DR5) signaling in AKT/ERK-overexpressing tumor cells. The PI3K/Akt signaling pathway and MAPK/ERK pathway are upregulated in a variety of tumor cell types and play a key role in tumor cell proliferation, differentiation and survival by inhibiting apoptosis. In addition, ONC201 is able to cross the blood-brain barrier." @default.
- NCIT_C113792 NCIT_A32 NCIT_C1909 @default.
- NCIT_C113792 NCIT_NHC0 "C113792" @default.
- NCIT_C113792 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C113792 NCIT_P108 "Dordaviprone" @default.
- NCIT_C113792 NCIT_P207 "C3710983" @default.
- NCIT_C113792 NCIT_P210 "1616632-77-9" @default.
- NCIT_C113792 NCIT_P319 "9U35A31JAI" @default.
- NCIT_C113792 NCIT_P322 "FDA" @default.
- NCIT_C113792 NCIT_P322 "GDC" @default.
- NCIT_C113792 NCIT_P329 "757339" @default.
- NCIT_C113792 NCIT_P330 "757339" @default.
- NCIT_C113792 NCIT_P375 "Akt/ERK Inhibitor ONC201" @default.
- NCIT_C113792 NCIT_P399 "757339" @default.
- NCIT_C113792 normalizedInformationContent "100" @default.
- NCIT_C113792 referenceCount "1" @default.
- NCIT_C113792 hasExactSynonym "Akt/ERK Inhibitor ONC201" @default.
- NCIT_C113792 hasExactSynonym "DORDAVIPRONE" @default.
- NCIT_C113792 hasExactSynonym "Dordaviprone" @default.
- NCIT_C113792 hasExactSynonym "ONC201" @default.
- NCIT_C113792 hasExactSynonym "TIC10" @default.
- NCIT_C113792 inSubset NCIT_C128784 @default.
- NCIT_C113792 inSubset NCIT_C157711 @default.
- NCIT_C113792 inSubset NCIT_C157712 @default.
- NCIT_C113792 inSubset NCIT_C176424 @default.
- NCIT_C113792 inSubset NCIT_C177537 @default.
- NCIT_C113792 inSubset NCIT_C63923 @default.
- NCIT_C113792 type Class @default.
- NCIT_C113792 isDefinedBy ncit.owl @default.
- NCIT_C113792 label "Dordaviprone" @default.
- NCIT_C113792 subClassOf NCIT_C113792 @default.
- NCIT_C113792 subClassOf NCIT_C129824 @default.
- NCIT_C113792 subClassOf NCIT_C129825 @default.
- NCIT_C113792 subClassOf NCIT_C1404 @default.
- NCIT_C113792 subClassOf NCIT_C155764 @default.
- NCIT_C113792 subClassOf NCIT_C174048 @default.
- NCIT_C113792 subClassOf NCIT_C1742 @default.
- NCIT_C113792 subClassOf NCIT_C1908 @default.
- NCIT_C113792 subClassOf NCIT_C1909 @default.
- NCIT_C113792 subClassOf NCIT_C2189 @default.
- NCIT_C113792 subClassOf NCIT_C274 @default.
- NCIT_C113792 subClassOf NCIT_C471 @default.
- NCIT_C113792 subClassOf NCIT_C61074 @default.