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- NCIT_C113793 IAO_0000115 "An orally available inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), with potential immunomodulating and antineoplastic activities. Upon administration, navoximod targets and binds to IDO1, a cytosolic enzyme responsible for the oxidation of the essential amino acid tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, this agent increases tryptophan levels, restores the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, and T-lymphocytes, and causes a reduction in tumor-associated regulatory T-cells (Tregs). Activation of the immune system, which is suppressed in many cancers, may induce a cytotoxic T-lymphocyte (CTL) response against the IDO1-expressing tumor cells. IDO1 is overexpressed by a variety of tumor cell types and plays an important role in immunosuppression. Tryptophan depletion is associated with immunosuppression caused by T-cell suppression." @default.
- NCIT_C113793 NCIT_A32 NCIT_C1909 @default.
- NCIT_C113793 NCIT_NHC0 "C113793" @default.
- NCIT_C113793 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C113793 NCIT_P107 "Navoximod" @default.
- NCIT_C113793 NCIT_P108 "Navoximod" @default.
- NCIT_C113793 NCIT_P208 "CL471774" @default.
- NCIT_C113793 NCIT_P210 "1402837-78-8" @default.
- NCIT_C113793 NCIT_P319 "926SHL95NC" @default.
- NCIT_C113793 NCIT_P322 "CTRP" @default.
- NCIT_C113793 NCIT_P322 "FDA" @default.
- NCIT_C113793 NCIT_P322 "GDC" @default.
- NCIT_C113793 NCIT_P329 "757383" @default.
- NCIT_C113793 NCIT_P330 "757383" @default.
- NCIT_C113793 NCIT_P375 "Navoximod" @default.
- NCIT_C113793 NCIT_P399 "757383" @default.
- NCIT_C113793 normalizedInformationContent "100" @default.
- NCIT_C113793 referenceCount "1" @default.
- NCIT_C113793 hasExactSynonym "5H-Imidazo(5,1-a)isoindole-5-ethanol, 6-Fluoro-alpha-(trans-4-hydroxycyclohexyl)-, (AlphaR,5S)-" @default.
- NCIT_C113793 hasExactSynonym "GDC-0919" @default.
- NCIT_C113793 hasExactSynonym "NAVOXIMOD" @default.
- NCIT_C113793 hasExactSynonym "NLG-919" @default.
- NCIT_C113793 hasExactSynonym "NLG919" @default.
- NCIT_C113793 hasExactSynonym "Navoximod" @default.
- NCIT_C113793 hasExactSynonym "RG6078" @default.
- NCIT_C113793 hasExactSynonym "RO7077339-001" @default.
- NCIT_C113793 inSubset NCIT_C116977 @default.
- NCIT_C113793 inSubset NCIT_C116978 @default.
- NCIT_C113793 inSubset NCIT_C128784 @default.
- NCIT_C113793 inSubset NCIT_C157711 @default.
- NCIT_C113793 inSubset NCIT_C157712 @default.
- NCIT_C113793 inSubset NCIT_C176424 @default.
- NCIT_C113793 inSubset NCIT_C177537 @default.
- NCIT_C113793 inSubset NCIT_C63923 @default.
- NCIT_C113793 type Class @default.
- NCIT_C113793 isDefinedBy ncit.owl @default.
- NCIT_C113793 label "Navoximod" @default.
- NCIT_C113793 subClassOf NCIT_C113793 @default.
- NCIT_C113793 subClassOf NCIT_C129820 @default.
- NCIT_C113793 subClassOf NCIT_C141137 @default.
- NCIT_C113793 subClassOf NCIT_C141144 @default.
- NCIT_C113793 subClassOf NCIT_C1908 @default.
- NCIT_C113793 subClassOf NCIT_C1909 @default.
- NCIT_C113793 subClassOf NCIT_C274 @default.
- NCIT_C113793 subClassOf NCIT_C308 @default.
- NCIT_C113793 subClassOf NCIT_C471 @default.