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- NCIT_C113796 IAO_0000115 "A humanized, bivalent anti-von Willebrand factor (VWF) nanobody with potential anti-platelet activity. Anti-von Willebrand factor nanobody specifically binds to the A1 domain of the VWF molecule, thereby inhibiting and neutralizing VWF activity. This prevents the interaction of VWF with the platelet glycoprotein (Gp)Ib-IX-V receptor and prevents VWF-mediated platelet aggregation. VWF is a glycoprotein and plays a key role in blood coagulation. Increased VWF, which is seen in a number of diseases, is associated with an increased risk in thrombosis. The nanobody formulation allows for rapid distribution, onset of action and clearance. The nanobody is based on the smallest functional fragments of single-chain antibodies that naturally occur in the Camelidae family." @default.
- NCIT_C113796 NCIT_NHC0 "C113796" @default.
- NCIT_C113796 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C113796 NCIT_P107 "Anti-von Willebrand Factor Nanobody" @default.
- NCIT_C113796 NCIT_P108 "Anti-von Willebrand Factor Nanobody" @default.
- NCIT_C113796 NCIT_P171 "19479665" @default.
- NCIT_C113796 NCIT_P208 "CL471778" @default.
- NCIT_C113796 NCIT_P322 "CTRP" @default.
- NCIT_C113796 NCIT_P329 "757591" @default.
- NCIT_C113796 NCIT_P330 "757591" @default.
- NCIT_C113796 NCIT_P399 "757591" @default.
- NCIT_C113796 normalizedInformationContent "100" @default.
- NCIT_C113796 referenceCount "1" @default.
- NCIT_C113796 hasExactSynonym "Anti-vWf Nanobody" @default.
- NCIT_C113796 hasExactSynonym "Anti-von Willebrand Factor Nanobody" @default.
- NCIT_C113796 inSubset NCIT_C116977 @default.
- NCIT_C113796 inSubset NCIT_C116978 @default.
- NCIT_C113796 inSubset NCIT_C176424 @default.
- NCIT_C113796 type Class @default.
- NCIT_C113796 isDefinedBy ncit.owl @default.
- NCIT_C113796 label "Anti-von Willebrand Factor Nanobody" @default.
- NCIT_C113796 subClassOf NCIT_C113796 @default.
- NCIT_C113796 subClassOf NCIT_C1327 @default.
- NCIT_C113796 subClassOf NCIT_C1908 @default.
- NCIT_C113796 subClassOf NCIT_C1909 @default.
- NCIT_C113796 subClassOf NCIT_C78275 @default.