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- NCIT_C113802 IAO_0000115 "A human monoclonal antibody targeting c-Met, with potential antineoplastic activity. Anti-c-Met monoclonal antibody ARGX-111 binds to c-Met, and blocks both ligand-dependent and -independent activation of c-Met-mediated signaling pathways. In addition, this agent enhances antibody dependent cellular cytotoxicity (ADCC). This leads to a reduction in cell proliferation of c-Met-expressing cancer cells. c-Met, a receptor tyrosine kinase overexpressed in certain cancer cell types, is involved in cell proliferation, angiogenesis and metastasis in multiple solid tumors. Compared to other c-Met targeting monoclonal antibodies, ARGX-111 shows increased antibody circulation time, enhanced tissue distribution and increased efficacy. ARGX-111 is obtained through active immunization with C-met antigen in Camelids and utilizes the Camelid V-domains fused with human antibody backbones." @default.
- NCIT_C113802 NCIT_A32 NCIT_C1909 @default.
- NCIT_C113802 NCIT_NHC0 "C113802" @default.
- NCIT_C113802 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C113802 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C113802 NCIT_P108 "Anti-c-Met Monoclonal Antibody ARGX-111" @default.
- NCIT_C113802 NCIT_P207 "C3827162" @default.
- NCIT_C113802 NCIT_P322 "GDC" @default.
- NCIT_C113802 NCIT_P329 "757660" @default.
- NCIT_C113802 NCIT_P330 "757660" @default.
- NCIT_C113802 NCIT_P375 "Anti-c-Met Monoclonal Antibody ARGX-111" @default.
- NCIT_C113802 NCIT_P399 "757660" @default.
- NCIT_C113802 NCIT_R124 NCIT_C17710 @default.
- NCIT_C113802 NCIT_R124 NCIT_C17828 @default.
- NCIT_C113802 NCIT_R124 NCIT_C18219 @default.
- NCIT_C113802 NCIT_R124 NCIT_C19986 @default.
- NCIT_C113802 NCIT_R124 NCIT_C40474 @default.
- NCIT_C113802 normalizedInformationContent "100" @default.
- NCIT_C113802 referenceCount "1" @default.
- NCIT_C113802 hasExactSynonym "ARGX-111" @default.
- NCIT_C113802 hasExactSynonym "Anti-c-Met Monoclonal Antibody ARGX-111" @default.
- NCIT_C113802 inSubset NCIT_C128784 @default.
- NCIT_C113802 inSubset NCIT_C157711 @default.
- NCIT_C113802 inSubset NCIT_C157712 @default.
- NCIT_C113802 inSubset NCIT_C176424 @default.
- NCIT_C113802 inSubset NCIT_C177537 @default.
- NCIT_C113802 type Class @default.
- NCIT_C113802 isDefinedBy ncit.owl @default.
- NCIT_C113802 label "Anti-c-Met Monoclonal Antibody ARGX-111" @default.
- NCIT_C113802 subClassOf NCIT_C113802 @default.
- NCIT_C113802 subClassOf NCIT_C129821 @default.
- NCIT_C113802 subClassOf NCIT_C129822 @default.
- NCIT_C113802 subClassOf NCIT_C163758 @default.
- NCIT_C113802 subClassOf NCIT_C164000 @default.
- NCIT_C113802 subClassOf NCIT_C164001 @default.
- NCIT_C113802 subClassOf NCIT_C1908 @default.
- NCIT_C113802 subClassOf NCIT_C1909 @default.
- NCIT_C113802 subClassOf NCIT_C20401 @default.
- NCIT_C113802 subClassOf NCIT_C274 @default.
- NCIT_C113802 subClassOf NCIT_C307 @default.
- NCIT_C113802 subClassOf NCIT_C308 @default.