Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C113804> ?p ?o ?g. }
Showing items 1 to 22 of
22
with 100 items per page.
- NCIT_C113804 IAO_0000115 "An orally available, stable powder formulation composed of sulforaphane, a naturally-occurring phytochemical belonging to the class of isothiocyanates, encapsulated within alpha-cyclodextrin, with chemopreventive activity. Upon administration of sulforaphane/alpha-cyclodextrin complex SFX-01, sulforaphane activates the transcription factor NF-E2-related factor 2 (Nrf2; NFE2L2), a member of the basic leucine zipper family, which binds to and activates antioxidant-response elements (AREs). Subsequently, activated AREs mediate the transcription of various cytoprotective genes and antioxidant enzymes, particularly phase II detoxification enzymes, such as glutathione-S-transferase and quinone oxidoreductase, resulting in the detoxification of highly reactive carcinogens. Cyclodextrin is able to prevent sulforaphane's rapid breakdown, which improves its stability and half-life." @default.
- NCIT_C113804 NCIT_NHC0 "C113804" @default.
- NCIT_C113804 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C113804 NCIT_P108 "Sulforaphane-cyclodextrin Complex" @default.
- NCIT_C113804 NCIT_P208 "CL471785" @default.
- NCIT_C113804 NCIT_P329 "757694" @default.
- NCIT_C113804 NCIT_P330 "757694" @default.
- NCIT_C113804 NCIT_P399 "757694" @default.
- NCIT_C113804 normalizedInformationContent "100" @default.
- NCIT_C113804 referenceCount "1" @default.
- NCIT_C113804 hasExactSynonym "SFX-01" @default.
- NCIT_C113804 hasExactSynonym "Stabilized Sulforaphane" @default.
- NCIT_C113804 hasExactSynonym "Sulforadex" @default.
- NCIT_C113804 hasExactSynonym "Sulforaphane-cyclodextrin Complex" @default.
- NCIT_C113804 inSubset NCIT_C176424 @default.
- NCIT_C113804 type Class @default.
- NCIT_C113804 isDefinedBy ncit.owl @default.
- NCIT_C113804 label "Sulforaphane-cyclodextrin Complex" @default.
- NCIT_C113804 subClassOf NCIT_C113804 @default.
- NCIT_C113804 subClassOf NCIT_C1892 @default.
- NCIT_C113804 subClassOf NCIT_C1908 @default.
- NCIT_C113804 subClassOf NCIT_C1909 @default.