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- NCIT_C114103 IAO_0000115 "A transdermal formulation containing 4-hydroxytestosterone (4-OHT), a steroidal aromatase inhibitor (AI) and androgen receptor (AR) antagonist, with potential antineoplastic activity. 4-OHT is largely converted into 4-hydroxyandrostenedione (4-OHA) and irreversibly binds to and inhibits aromatase, thereby blocking the conversion of androstenedione to estrone, and testosterone to estradiol. This may inhibit tumor cell proliferation in estrogen-dependent tumor cells. In addition, 4-OHT binds to the AR and may inhibit AR-mediated tumor cell growth. Aromatase, a cytochrome P-450 enzyme, is overexpressed in a variety of cancer cells; it plays a key role in estrogen biosynthesis. Compared to oral 4-OHT, the transdermal formulation allows for continuous release of 4-OHT into the bloodstream and prevents first pass metabolism by the liver." @default.
- NCIT_C114103 NCIT_A32 NCIT_C1909 @default.
- NCIT_C114103 NCIT_NHC0 "C114103" @default.
- NCIT_C114103 NCIT_P106 "Organic Chemical" @default.
- NCIT_C114103 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C114103 NCIT_P108 "Transdermal 4-Hydroxytestosterone" @default.
- NCIT_C114103 NCIT_P208 "CL471813" @default.
- NCIT_C114103 NCIT_P322 "GDC" @default.
- NCIT_C114103 NCIT_P329 "758421" @default.
- NCIT_C114103 NCIT_P330 "758421" @default.
- NCIT_C114103 NCIT_P375 "Transdermal 4-Hydroxytestosterone" @default.
- NCIT_C114103 NCIT_P399 "758421" @default.
- NCIT_C114103 normalizedInformationContent "100" @default.
- NCIT_C114103 referenceCount "1" @default.
- NCIT_C114103 hasExactSynonym "Transdermal 4-Hydroxytestosterone" @default.
- NCIT_C114103 hasExactSynonym "Transdermal 4-OHT" @default.
- NCIT_C114103 hasExactSynonym "Transdermal CR1447" @default.
- NCIT_C114103 inSubset NCIT_C128784 @default.
- NCIT_C114103 inSubset NCIT_C157711 @default.
- NCIT_C114103 inSubset NCIT_C157712 @default.
- NCIT_C114103 inSubset NCIT_C176424 @default.
- NCIT_C114103 inSubset NCIT_C177537 @default.
- NCIT_C114103 type Class @default.
- NCIT_C114103 isDefinedBy ncit.owl @default.
- NCIT_C114103 label "Transdermal 4-Hydroxytestosterone" @default.
- NCIT_C114103 subClassOf NCIT_C114103 @default.
- NCIT_C114103 subClassOf NCIT_C129818 @default.
- NCIT_C114103 subClassOf NCIT_C129824 @default.
- NCIT_C114103 subClassOf NCIT_C129825 @default.
- NCIT_C114103 subClassOf NCIT_C147908 @default.
- NCIT_C114103 subClassOf NCIT_C163758 @default.
- NCIT_C114103 subClassOf NCIT_C1740 @default.
- NCIT_C114103 subClassOf NCIT_C1908 @default.
- NCIT_C114103 subClassOf NCIT_C1909 @default.
- NCIT_C114103 subClassOf NCIT_C2017 @default.
- NCIT_C114103 subClassOf NCIT_C2189 @default.
- NCIT_C114103 subClassOf NCIT_C274 @default.
- NCIT_C114103 subClassOf NCIT_C471 @default.
- NCIT_C114103 subClassOf NCIT_C481 @default.
- NCIT_C114103 subClassOf NCIT_C547 @default.