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- NCIT_C114293 IAO_0000115 "A dendritic cell (DC)-based cancer vaccine composed of autologous, type-1 polarized dendritic cells (DCs) pulsed with human leukocyte antigen (HLA)-A2-restricted HER-2-derived peptides, with potential immunomodulatory and antineoplastic activities. Autologous DCs were treated with GM-CSF, interleukin-4, interferon-gamma and bacterial lipopolysaccharide (LPS), a toll-like receptor type 4 agonist, to produce highly polarized DCs (alphaDC1) that are capable of producing high levels of interleukin-12p70 (IL-12p70). Upon administration, HER2-pulsed autologous DC vaccine may stimulate a potent cytotoxic T-lymphocyte (CTL) response against HER-2-positive tumor cells, which may result in tumor cell death and decreased tumor growth. HER-2, a tyrosine kinase receptor for epidermal growth factor (EGF) (also known as neu and ErbB2), is overexpressed by a variety of cancers." @default.
- NCIT_C114293 NCIT_NHC0 "C114293" @default.
- NCIT_C114293 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C114293 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C114293 NCIT_P108 "HER2-pulsed Autologous Type-1 Polarized Dendritic Cell Vaccine" @default.
- NCIT_C114293 NCIT_P208 "CL472222" @default.
- NCIT_C114293 NCIT_P329 "758205" @default.
- NCIT_C114293 NCIT_P330 "758205" @default.
- NCIT_C114293 NCIT_P399 "758205" @default.
- NCIT_C114293 normalizedInformationContent "100" @default.
- NCIT_C114293 referenceCount "1" @default.
- NCIT_C114293 hasExactSynonym "HER-2 pulsed DC1 Vaccine" @default.
- NCIT_C114293 hasExactSynonym "HER2-pulsed Autologous Type-1 Polarized Dendritic Cell Vaccine" @default.
- NCIT_C114293 inSubset NCIT_C128784 @default.
- NCIT_C114293 inSubset NCIT_C176424 @default.
- NCIT_C114293 type Class @default.
- NCIT_C114293 isDefinedBy ncit.owl @default.
- NCIT_C114293 label "HER2-pulsed Autologous Type-1 Polarized Dendritic Cell Vaccine" @default.
- NCIT_C114293 subClassOf NCIT_C114293 @default.
- NCIT_C114293 subClassOf NCIT_C129820 @default.
- NCIT_C114293 subClassOf NCIT_C1663 @default.
- NCIT_C114293 subClassOf NCIT_C1908 @default.
- NCIT_C114293 subClassOf NCIT_C1909 @default.
- NCIT_C114293 subClassOf NCIT_C274 @default.
- NCIT_C114293 subClassOf NCIT_C28308 @default.
- NCIT_C114293 subClassOf NCIT_C28310 @default.
- NCIT_C114293 subClassOf NCIT_C307 @default.
- NCIT_C114293 subClassOf NCIT_C308 @default.
- NCIT_C114293 subClassOf NCIT_C923 @default.