Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C114294> ?p ?o ?g. }
Showing items 1 to 37 of
37
with 100 items per page.
- NCIT_C114294 IAO_0000115 "A genetically engineered, replication selective, infected cell protein (ICP) 34.5 gene-deleted, oncolytic human simplex virus type 1 (HSV-1) expressing the human immunostimulating cytokine interleukin-12 (IL-12), with potential antineoplastic activity. Upon intratumoral administration of HSV-1 expressing IL-12 NSC 733972, the IL-12-expressing HSV-1 preferentially infects and replicates in tumor cells of neuronal origin causing viral-mediated tumor cell lysis. The released virus particles, in turn, infect and replicate in neighboring tumor cells. In addition, the IL-12-expressing HSV-1 promotes the secretion of IL-12 by the tumor cells. IL-12 promotes the activation of natural killer cells, which induces both the secretion of interferon-gamma and a cytotoxic T-lymphocyte (CTL) response against the tumor cells. This results in both immune-mediated tumor cell death and further inhibition of tumor cell proliferation. Deletion of the gene encoding for ICP34.5 imparts tumor selectivity by preventing replication in healthy cells." @default.
- NCIT_C114294 NCIT_A32 NCIT_C1909 @default.
- NCIT_C114294 NCIT_NHC0 "C114294" @default.
- NCIT_C114294 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C114294 NCIT_P106 "Virus" @default.
- NCIT_C114294 NCIT_P107 "IL-12-expressing HSV-1 NSC 733972" @default.
- NCIT_C114294 NCIT_P108 "IL-12-expressing HSV-1 NSC 733972" @default.
- NCIT_C114294 NCIT_P208 "CL471805" @default.
- NCIT_C114294 NCIT_P322 "CTRP" @default.
- NCIT_C114294 NCIT_P322 "GDC" @default.
- NCIT_C114294 NCIT_P329 "758218" @default.
- NCIT_C114294 NCIT_P330 "758218" @default.
- NCIT_C114294 NCIT_P375 "IL-12-expressing HSV-1 NSC 733972" @default.
- NCIT_C114294 NCIT_P399 "758218" @default.
- NCIT_C114294 normalizedInformationContent "100" @default.
- NCIT_C114294 referenceCount "1" @default.
- NCIT_C114294 hasExactSynonym "IL-12-expressing HSV-1 NSC 733972" @default.
- NCIT_C114294 hasExactSynonym "M032" @default.
- NCIT_C114294 hasExactSynonym "NSC 733972" @default.
- NCIT_C114294 inSubset NCIT_C116977 @default.
- NCIT_C114294 inSubset NCIT_C116978 @default.
- NCIT_C114294 inSubset NCIT_C128784 @default.
- NCIT_C114294 inSubset NCIT_C157711 @default.
- NCIT_C114294 inSubset NCIT_C157712 @default.
- NCIT_C114294 inSubset NCIT_C176424 @default.
- NCIT_C114294 inSubset NCIT_C177537 @default.
- NCIT_C114294 type Class @default.
- NCIT_C114294 isDefinedBy ncit.owl @default.
- NCIT_C114294 label "IL-12-expressing HSV-1 NSC 733972" @default.
- NCIT_C114294 subClassOf NCIT_C114294 @default.
- NCIT_C114294 subClassOf NCIT_C129821 @default.
- NCIT_C114294 subClassOf NCIT_C1908 @default.
- NCIT_C114294 subClassOf NCIT_C1909 @default.
- NCIT_C114294 subClassOf NCIT_C1962 @default.
- NCIT_C114294 subClassOf NCIT_C274 @default.
- NCIT_C114294 subClassOf NCIT_C307 @default.
- NCIT_C114294 subClassOf NCIT_C717 @default.